대한핵의학회지 (1967년~2009년)
대한핵의학회지 1967;1(1)79~4
재생불량성빈혈에 대한 Androgen 요법 (속보) : Androgen 의 효과와 Ferrokinetics Index 및 EEI와의 관계 ( Patients with aplastic anemia were treated with a combination of depo-testosterone cyclopentylpropionate (Upjohn) and dexamethasone. In 7 of 15 patients
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Author 황기석(K S Hwang),
Affiliation
Abstract

Patients with aplastic anemia were treated with a combination of depo-testosterone cyclopentylpropionate (Upjohn) and dexamethasone. In 7 of 15 patients treated, there was response in which either a significant increase in hemoglobin concentration, a prolonged interval or a cessation of blood transfusion requirement developed during androgen therapy. Younger patients with cellular marrow appeared to be better responding to androgen. EEI (Effective Erythropoietic Index) formulated by Gardner & Nathan (1966) which was a helpful measurement as to whether patients with myelofibrosis would respone to androgen, was evaluated in patients with aplastic anemia. It was concluded that EEI as well as ferrokinetics indices (Plasma-59Fe-disappearance rate, RBC 59Fe net incorporation) did not significantly correlate with the degree of response to androgen in aplastic anemia.

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