대한핵의학회지 (1967년~2009년)
대한핵의학회지 1967;1(2)61~14
구충성빈혈에 관한 연구 ( The Study on the Ferrokinetics and Acquired Immunity in Repeated Hookworm Infections )
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Author 이문호(Mun Ho Lee),이필웅(Pyl Ung Lee),
Affiliation
Abstract

In order to confirm whether acquired immunity or resistance can be developed by the repeated hookworm infections, the 150 mature actively moving filariform ancylostoma duodenale larvae obtained from the severe hookworm anemia patients were orally given to 8 healthy volunteers in three divided doses, 50 in each, at 5 day interval. Also the hematological changes as well as several ferrokinetics using 59Fe were done and were compared with 10 controls. The clinical symptoms and signs were checked every day for the first 3 weeks and then twice weekly until the end of the experiment. The appearance of the ova in the stool was examined by the formalin ether method and the ova was counted by the Stoll's method. The following laboratory tests were done:1) Red blood cell count, venous blood hematocrit (micromethod), hemoglobin count (cyanomethemoglobin method) were checked every 5 to 7 day interval. 2) Plasma iron concentration (Barkan's modified method) was determined every 2 to 3 week interval. 3) Radioistope studies:a) Ferrokinetics: Huff et al and Bothwell's method were applied. Erythropoietic Index (% of normal)= {"Subject's turnover/100ml whole blood¡¿100" } over {"Average normal turnover/100ml whole blood" } b) Quantitative measurement of the gastrointestinal absorption of iron:Radioiron (59Fe) balance method was applied. c) Determination of the plasma erythropoietin activity:Fried's method was applied. Following were the results:1) The serum iron level was lower. The red cell voiume was decreased, but with relative increase of plasma volume. 2) The plasma iron disappearance time was accelerated and the plasma iron turnover rate was decreased. The red cell iron turnover rate was markedly increased, while all of the red cell iron concentration, circulating red cell iron, plasma iron pool were decreased. The daily iron pool turnover and red cell renewal rate were increased. 3) The erythropoietic index, erythropoietin activity and intestinal absorption of iron (59Fe) were markedly increased. 4) The infectivity was 9.8¡¾1.31% which ivas lower than that observed in the single infection. 5) From these observations, it is concluded that the hookworm anemia is essentially iron deficieny in its origin and some immunity acquisition is possible with repeated infections.

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