대한핵의학회지 (1967년~2009년)
대한핵의학회지 1969;3(1)51~8
방사성동위원소옥소(131I)의 치료량이 갑상선종환자의 혈액상에 미치는 영향에 관한 연구 ( A study on the Hematologic Effects of Radioactive Iodine(131I) Therapy on Various Thyroid Diseases )
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Author 김명재(Myung Jae Kim),김노경(Noe Kyeong Kim),이정상(Jung Sang Lee),최근출(Keun Chul Choi),이영우(Young Woo Lee),김기원(Kee Won Kim),강신일(Shin Il Kang),
Affiliation
Abstract

To clarify the hematologic effects of the radioiodine (131I) in therapeutic doses (5∼10mCi) on the various thyroid patients, authors studied the peripheral blood pictures of 396 goitrous patients before and after radioiodine (131I) administrations in the Isotope Clinic of Seoul National University Hospital. Among these 396 cases of goiters, we gave 5 to 10mCi of radioiodine (131I) with single or fractionated administrations. The blood pictures of non-treated thyroid patients were compared with that of normal Korean values to clarify any difference between normal and goiter. The blood pictures of hyperthyroid patients treated with 131I therapy were compared with the blood pictures of non-treated thyroid patients. The results were as following:1) The incidence according to type: Toxic diffuse goiter:35.4%. Nontoxic nodular goiter:29.7%. Euthyroid:13.8%. Nontoxic diffuse goiter:12.6%. Hypothyroidism:4.3%. Thyroiditis(s subacute form):1.8%. Toxic nodular goiter:1.4%. Malignancy:1.0%. 2) Age incidence: The range of distribution was 11 to 71 years. The peak incidence was found in the 4th decade of life. 80.6∼82.6% of those 396 cases were found among the 3rd, 4th and the 5th decades of life. 3) Sex incidence:Sex ratio of male:female was 1:7.8. 4) The most outstanding findings in peripheral blood before treatment were decreased erythrocyte count and hemoglobin value in all types of thyroid diseases, especially in the cases of hypothyroidism and thyroiditis. Hook worm-infested patients showed no significant difference in erythrocytes and hemoglobin values from those of other hook worm free patients. 5) Total leukocytes count was within normal range. Differential count of W.B.C. showed increased percentile of lymphocyte in diffuse toxic goiter and thyroiditis. 6) 39 cases of diffuse goiter treated with 131I toxic showed amelioration in the anemia and restoration to normal range of lymphocyte count in association with increased percentile of neutrophiles 3 months after administration, except a case of toxic nodular goiter. One can observe anemia in slight degree, and increased lymphocytes count in hypothyroidism. Therapeutic dose of radioiodine (131I) dose not result any residual effect on the hematopoietic function. Radioiodine (131I) therapy resulted in improvement of thyroid function in association of amelioration of pevious abnormal blood pictures. 7) Authors did not observe any myxedema resulted from radioiodine therapy during the 3 months period in this study.

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