만성 간 질환에서 경구적 당부하 시험시 혈당 및 혈장 인슐린의 변동에 관한 연구 ( A Study on the Glucose and Immunoreactive Insulin Response during Oral Glucose Tolerance Test in Patients with Chronic Liver Diseases ) () |
Author |
최강원(Kang Won Choe),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),이문호(Mun Ho Lee), |
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Abstract |
The blood glucose and plasma immunoreaetive
insulin(IRI) levels were measured during aral glucose
tolerance test in 7 healthy subjects and 6 patients
with chronic liver diseases. The glucose tolerance was
impaired in 5 of the 6 patients and normal in I. Plasma
IRI responses were markedly increased and delayed in
all patients, suggesting endogenous insulin resistance.
Patients with more glucose intolerance showed less
increase in plasma IRI than the group with less
intolerance. lt is suggested that some insulin
antagonists may decrease the peripheral insulin
sensitivity and stimulate compensatory hyperactivity of
pancreatic islets. If the compensatory hyperactivity is
inadequate due to gemetic predisposition to diabetes
mellitas or exhaustion of β-cells of pancreatic
islsts, the glucose intolerance and overt diabetes
mellitus may ensue. |
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Full text Article |
28502924.pdf
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