대한핵의학회지 (1967년~2009년)
대한핵의학회지 1980;14(2)35~6
갑상선기능항진증의 내과적 치료효과 ( Medical Therapeutic Effect of Hyperthyroidism:Comparison of antithyroid therapy and 131I Therapy )
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Author 이규보(K. B. Lee),
Affiliation
Abstract

In order to compare the therapeutic effect as well as side effects between antithyroid therapy and radioiodine therapy in hyperthyroidism, the author evaluated 111 cases of hyperthyroidism which were composed of 57 patients with antithyroid treatment, 23 patients with combined treatment comprising of antithyroid and radioactive iodine (131I) and 31 patients with treatment of 131I alone. The 131I treatment was limited to older age, above 20 years of age, and not employed in patients with pregnancy and lactation. The patients treated with antithyroid belonged to relatively younger age, and also milder in symptoms and thyroid function tests. The remission rate of antithyroid therapy group was 97.8% within 16 months. Among them the early remission rate occured within 4 months was found to be 21.7%. The combined therapy group, having prescribed more severe cases, showed the remission rateto be 75% within 16 months. The emission rate of 131I therapy group revealed 90.9% within 16 months. Among them the early remission rate taking place within 4 monthr, disclosed 16.7%. The side effects of antithyroid drug, propylthiouracil, were noted as follows: itching(2.7%) skin rashes (1.3%), and adverse enlargement of goiter (10.7%). The side effects 131I therapy were transient hypothyroidism(3.9%) permanent hypothyroidism(7.8%) and itching (2.0%).

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