Tc-99m-Sulfur Colloid is concentrated in Kupffer cells of the liver, whereas the new biliary agents such as Tc-99m- HIDA are processed by hepatic parenchymal cells. The distant metastatic lesions in skull and lung of the primary hepatoceullar carcinoma in 38-year old Korean male were detected with Tc-99m-HIDA scintigraphy. The chest PA, skull bone X-ray and radionuclide scintigraphic studies are illustrated. This observation suggests that Tc-99m-HIDA scintigraphy is useful for detection of distant metastases of primary hepatocellular carcinoma.