대한핵의학회지 (1967년~2009년)
대한핵의학회지 1984;18(1)39~6
정상 한국인의 혈중 Glucagon 의 동태에 관한 연구 ( Study on the Diurnal Variation of the Plasma Immunoreactive Glucagon )
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Author 이홍규(Hong Kyu Lee),정준기(Jung Key Chung),김의종(Eui Chong Kim),홍기석(Kee Suk Hong),김병국(Byoung Kook Kim),고창순(Chang Soon Koh),
Affiliation
Abstract

It is well known that glucagon, like insulin, is very important in the moment-to-moment control of the homeostasis of glucose, and of amino acids. Glucagon has been shown to have potent glycogenolytic, gluconeogenic and lipolytic activities. Attention to its role in the pathogenesis of diabetes mellitus and hypoglycemia has been also advanced recently. To evaluate the diurnal variation of plasma glucagon concentration, we measured serum glucose, insulin, and plasma glucagon every 30 minutes or every hour in 7 normal Korean adults. Results were as follows: 1) Although plasma glucagon concentration showed wide individual variations, it had a tendency to decrease after meals. After lunch and dinner, plasma glucagon concentration had gradual1y declined and reached its nadir at postprandial 2-2.5 hours. The minimal level of plasma glucagon was at 4 A.M. 2) Serum insulin:plasma glucagon ratios were increased promptly after meals. Especially after lunch, its peak was prominent (3.65¡¾1. 95). The minimal level of serum insulin:plasma glucagon ratio appeared at 6 AM.

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