대한핵의학회지 (1967년~2009년)
대한핵의학회지 1985;19(1)127~10
각종 신질환에서의 혈청 β2 - microglobulin 측정의 의의 ( The Significance of Serum Beta2-Microglobulin Measurement in Various Renal Diseases )
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Author 궁성수(Sung Soo Koong),오하영(Ha Yong Oh),한진석(Jin Suk Han),이정상(Jung Sang Lee),
Affiliation
Abstract

To evaluate change of serum beta2-microglobulin concentration (sβ2-MG) and the usefulness of sβ2-MG and sβ2-MG/serum creatinine concentration (sCr) ratio in various renal diseases, sβ2-MG and sCr were measured in 25 normal controls and 90 patients of various renal diseases (16 cases of glomerulonephritis, 12 cases of acute renal failure, 8 cases of chronic renal failure, 24 cases of nephrotic syndrome, 15 cases of tubulointerstitial diseases and 15 cases of lupus nephritis) using Phadebasⓡ Beta2-Micro Test kits. The results were as follows; 1) In normal control, the mean value of sβ2-MG was 1.65±0.41 mg/ι and the mean value of sβ2-MG/sCr ratio was 0.14±0.05. 2) In various renal diseases, the mean value of sβ2-MG was 6.74±5.47 mg/ι. The mean value of sβ2-MG/sCr ratio was 0.24±0.11 and significantly elevated than that of normal contro1. (P〈0.05). 3) The correlation between sβ2-MG and sCr in glomerular and tubulointerstitial disease was log sβ2-MG=0.90 log sCr-0.48 and its correlation coefficient was 0.78 (P〈0.05). 4) In glomerular disease, the correlation between sβ2-MG and sCr was log sβ2-MG=0.89 log sCr-0.46 (r-0.76) and in tubulointerstitial disease, it was log sβ2-MG=0.95 1og sCr-0.59 (r-0.87). There was no significant difference between the two groups (p〈0.05). 5) Among 32 cases of glomerular and tubulointerstitial disease patients, whose sCr was within normal range, 17 cases showed elevated sβ2-MG. The mean values of sβ2-MG/sCr ratio in these patients was 0.30±0.14 and significantly elevated than that of normal control (p〈0.05). 6) In 15 cases of lupus nephritis, 12 cases showed elevated sβ2-MG with normal sCr and 12 cases showed elevated sβ2-MG/sCr ratio. With above results, It was found that the sβ2-MG can be used as an index of glomerular filtration rate as in the case of sCr and thats sβ2- MG/sCr ratio can be used as a tool in early detection of slightly decreased glomerular filtration rate and in detection of the renal disease of increased β2-MG production.

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