Abstract |
To evaluate change of serum beta2-microglobulin
concentration (sβ2-MG) and the usefulness of sβ2-MG
and sβ2-MG/serum creatinine concentration (sCr) ratio
in various renal diseases, sβ2-MG and sCr were
measured in 25 normal controls and 90 patients of
various renal diseases (16 cases of glomerulonephritis,
12 cases of acute renal failure, 8 cases of chronic
renal failure, 24 cases of nephrotic syndrome, 15 cases
of tubulointerstitial diseases and 15 cases of lupus
nephritis) using Phadebasⓡ Beta2-Micro Test kits. The
results were as follows; 1) In normal control, the mean
value of sβ2-MG was 1.65±0.41 mg/ι and the mean
value of sβ2-MG/sCr ratio was 0.14±0.05. 2) In
various renal diseases, the mean value of sβ2-MG was
6.74±5.47 mg/ι. The mean value of sβ2-MG/sCr ratio
was 0.24±0.11 and significantly elevated than that of
normal contro1. (P〈0.05). 3) The correlation between
sβ2-MG and sCr in glomerular and tubulointerstitial
disease was log sβ2-MG=0.90 log sCr-0.48 and its
correlation coefficient was 0.78 (P〈0.05). 4) In
glomerular disease, the correlation between sβ2-MG and
sCr was log sβ2-MG=0.89 log sCr-0.46 (r-0.76) and in
tubulointerstitial disease, it was log sβ2-MG=0.95 1og
sCr-0.59 (r-0.87). There was no significant difference
between the two groups (p〈0.05). 5) Among 32 cases of
glomerular and tubulointerstitial disease patients,
whose sCr was within normal range, 17 cases showed
elevated sβ2-MG. The mean values of sβ2-MG/sCr ratio
in these patients was 0.30±0.14 and significantly
elevated than that of normal control (p〈0.05). 6) In
15 cases of lupus nephritis, 12 cases showed elevated
sβ2-MG with normal sCr and 12 cases showed elevated
sβ2-MG/sCr ratio. With above results, It was found
that the sβ2-MG can be used as an index of glomerular
filtration rate as in the case of sCr and thats sβ2-
MG/sCr ratio can be used as a tool in early detection
of slightly decreased glomerular filtration rate and in
detection of the renal disease of increased β2-MG
production. |