갑상선질환에서 갑상선 자극면역글로불린측정의 의의에 관한 연구 - Micro 법 갑상선세포배양에 의한 측정의 기본적 검토 - ( Thyroid Stimulating Immunoglobulin Bioassay Using Cultured Human Thyroid Cells ; A Simplified Micromethod )
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| Author |
이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),고창순(Chang Soon Koh),이문호(Mun Ho Lee),안일민(Il Min Ahn),안희권(Hee Kwon Ahn), |
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| Affiliation |
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| Abstract |
The activation of adenylate cyclase of human thyrocytes
in primary cell culture and the release of c-AMP into
the medium are used to detect b-TSH and TSAb in sera of
patients with autoimmune thyroid disease. Sera of
patients are used directly as a part of cell culture
without immunoglobulin precipitation. In the above TSI
bioassay, TSAb pooled serum show c-AMP concentration
between that of 1 mU/ml and 10 mU/ml b-TSH but normal
control pooled serum doesn't show any detectable c-AMP
response. Ninety five percent of untreated Graves'
patients shows TSAb activity above normal range, 20% of
Hashimoto's and 363/0 of euthyroid Graves' patients
show detectable TSAb activity. |
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| Full text Article |
28500537.pdf 
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