Abstract |
It is well known that Tc-99m-sulfur colloid or phytate
hepatic scintigraphy is highly sensitive but not
specific. Both Tc-99m-DISIDA and bilirubin have been
shown to share the same anionic transport pathway in
the liver. Hepatocellular carcinoma (HCC) retains the
ability to produce bile but has marked limitation to
excreting it resulting in accumulation of bile within
the tumor cells. Based upon such a fact, Tc-99m-DISIDA
hepatobiliary scintigraphy is used for the diagnosis of
HCC. The present communication deals with our
experience of DISIDA scintigraphic exploration of 9
cases of HCC in a retrospective way. We have made an
observation on intensity of positive radionuclide
accumulation in the cold area of HCC as it is
demonstrated by phytate scintigraphy. In addition we
have semiquantitatively analyzed time-activity pattern
and the following results were obtained.(1) All of 9
cases showed an increased uptake of Tc-99m-DISIDA in
delayed scintigrams. Of these 5 cases showed
accumulation less than, 3 equal to, 1 more than the
surrounding liver tissue. (2) The mean of the first
appearing time of Tc-99m-DISIDA activity in tumoral
region was 2 hours and 20 minutes. (3) DISIDA
scintigraphy provides us with positive informations of
diagnostic value. |