Abstract |
It is well-known that hepatic scintigraphy have been
found to be less sensitive and specific in the
detection of the diffuse hepatocellular diseases than
that of the space-occupying lesions. To obtain the
higher diagnostic specificity and sensitivity, we,
using the computer quantitation, have attempted to
analyze hepatic and extrahepatic Tc-99m-tin colloid
uptake patterns in various diffuse hepatocellular
diseases retrospectively. The studied groups consisted
of 116 cases of normal, 67 cases of acute hepatitis,
112 cases of chronic hepatitis, 61 cases of liver
cirrhosis, 47 cases of fatty liver, 12 cases of
hepatoma and 9 cases of metastasis, making total 424
cases. Scintigraphic imagings were obtained in the
anterior, right lateral and posterior projections using
high-resolution collimation, and simultaneously these
gamma data were acquisited into the computer system.
Both large region of interest (ROI) using light pen and
ROI computer program were placed over right lobe, left
lobe of liver, spleen and cardiac blood pool. Total
counts in ROI were divided by the number of pixels in
the ROI, and mean count rate per pixels calculated.
Mean right-lobe counts were divided by mean-left lobe
counts to determine right-to-left hepatic lobe ratio
and mean spleen counts were divided by mean liver
counts to determine spleen to liver ratio. The results
were as follows. 1) Of 424 cases, 292 were male and 132
were female. The majority of age distribution was in
30∼49 (54.5%). 2) Inter-observer between two
independant operators and inter-method between drawing
by light-pen and ROI computer program variations were
not significant. 3) The uptake count values (per pixel)
determined at each area in normal group were
106.53±18.35 in right lobe, 79.00±13.82 in left lobe,
17.52±8.31 in spleen and 8.09±3.43 in cardiac blood
pool. 4) In liver cirrhosis, right lobe uptake was
decreased but spleen and cardiac blood pool uptakes
were increased (p〈0.01). 5) Right-to-left hepatic lobe
uptake ratio was 1.37±0.24 in normal group and s |