Abstract |
To evaluate the values of the thyroid autoantibody
measured by radioimmunoassay (RIA) and compare it with
hemagglutination method (HA) in the normal and the
thyroid disease, data were obtained from total 61B
persons; 236 healthy persons, 217 patients with Graves
disease (including 113 patients with undertreated
Graves disease'), 100 Hashimotos disease, 31 thyroid
nodule, and 34 simple goiter. RSR kit made in England
was used and could be detected t:o at least 3 U/ml. The
positive rates of normal group were antirnicrosomal
antibody (AMA) 31.8%, antithyroglobulin antibody (ATA)
44.5% by RIA and there was no considerable change in
sex and age distribution. 1n Graves disease, the
positive rates of AMA and ATA were 90.4, 76.9% by RIA,
85, 39% by HA. In Hashimotos disease, 94,91% by RIA,
and 87,48% by HA, respectively. The autoantibody titer
by RIA in thyroid autoimmune disease as welt as in
normal group was more senisit.ive than that by HA,
especially in ATA. There were linear relationships
between the titer of RIA and that of HA in AMA of
Graves disease and AMA and ATA of Hashimotos disease.
There was no relationship among thyroid autoantibody,
free T, index, TBII, and TSH. The titers of AMA and ATA
were found to decrease in patients with Graves disease
during the course of antithyroid drug therapv. Of the
236 normal subjects, thirty-seven (15.7%) had
concentrations of above 7.5 U/ml in AMA, forty-four
(18. 6%) above 9 U/ml in ATA. These values were
considered as the upper limit for the normal range. In
Graves disease, 82,7, 53.8% were above 7.5, 9 U/ml,
respectively;1n Hashimoto's disease, HZ, 79% were
positive. We conclude that RIA was more sensitve than
HA in measuring the thyoird autoantibody, but we will
study further more for determining the normal range and
its interpretation. |