대한핵의학회지 (1967년~2009년)
대한핵의학회지 1988;22(1)77~5
흰쥐 육종 180 에서 169Yb-Citrate 의 종양 친화성 ( Accumulation of 169Yb Citrate in Tumor Bearing Mice )
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Author 김장휘(Jang Hee Kim),홍성운(Sung Woon Hong),임상무(Lim Sang Moo),이진오(Jhin Oh Lee),
Affiliation
Abstract

Tumor localizing properties of 67Ga citrate and 169Yb citrate were studies with sarcoma 180 bearing mice. To compare precisely the accumulation of 67Ga citrate and 169Yb citrate in tumor tissue itself, 67Ga and 169Yb were administered simultaneously as a mixture of same chemical form of citrate. The yield of 169Yb labeled citrated and the of radiopharmaceuticals purity was identified more than 90% by chromatography on silica gel plates. 67Ga and 169Yb were injected into mice and the mice were killed at 3, 24, and 48 hours following intraperitoneal injection of the radiopharmaceuticals. The retention value of 67Ga and 169Yb in tumor was similar but they differ from each other markedly in normal tissue distribution. 169Yb citrate is cleared up from blood more rapidly than 67Ga citrate, and a high tumor to blood ratio is achieved shortly after injection.

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