원저 : Cisplatin의 투여 후 사구체여과율 및 신혈류량의 변화 ( Effect of Cisplatin on Glomerular Filltration Rate and Effective Renal Plasma Flow ) () |
Author |
임상무(Sang Moo Lim),홍성운(Seong Woon Hong),김용현(Young Hyun Kim),홍원선(Weon Seon Hong),송재관(Jae Kwan Song),김영환(Young Whan Kim),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang), |
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Abstract |
While cisplatin has been widely used in the treatment
of a variety of cancers, nephrotoxicity is one of the
major problems which frequently limit clinical
usefulness of cisplatin. This study has been conducted
to investigate nephrotoxicity of cisplatin in terms of
changes in glomerular filtration rate (GFR) and
effective renal plasma flow (EFPF) measured by the
simultaneous use of Tc-99m-DTPP and-131I-OIH, before
and after administration of cisplatin, in 12 patients
with lung cancer and four patients with esophageal
cancer. Cisplatin was administrated at total doses of
75∼100 mg/㎡ with two hour hydration and diuresis
method. GFR determined by the use of Tc- 99m-DTPA had a
good correlation with 24-hour creatinine clearance rate
(r=0.77, p〈0.001). GFR and filtration fraction
decreased immediately after administration of
cisplatin, however, they showed a tendency to be in
completely recovered four weeks after administration.
ERPF was not changed immediately after and four weeks
after administration of cisplatin. GFR before and
immediately after administration of cisplatin were
analyzed with regard to age, sex, performance status,
previous adminstration of cisplatin and method of
administration. None of these factors had any influence
on the rate of decrease in GFR except method of
administration. Administration of cisplatin as a single
dose lowered GFR more compared with that as divided
doses. In this study, we have also demonstrated that
the simultaneous use of Tc-99m-DTPA and 131I-OIH was a
useful tool for the measurement of GFR and ERPF
respectively. |
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Full text Article |
28500873.pdf
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