To observe the effect of gastric filling on the images of hepatic scintigraphy, we performed hepatic scintigraphy using '" Tc-tin colloid in twenty patients hoth in the fasting state and after meal, and made the visual comparison of both irnages. We found that gastric filling could cause some of the followillg changes in individual patients. 1) In the anterior view, t.he distance between the liver and the spleen increased and the interlobar notch of the inferior hepatic horder was obliterated, The spleen was displaced downwards, its radioactivity in the upper medial part was reduced, and its upper pole was laterally displaced. 2) In the poosterior view, the left lobe of the liver was separated from the spleen and the distance between the liver and the spleen increased. 3) In the right lateral view, the notch separating the right and the left lobes of the liver was well demarcated. 4) In the left lateral view, the spleen was separated from the liver and the distance between the liver and the spleen dicreased. The shape of the splen was also changed. In case of the follow up study, above changes should make one consider the possibility of the effect of gastric filling.