Author |
염미경(Mi Kyoung Yeom),정재민(Jae Min Jeong),진광호(Kwang Ho Jin),조규진(Kyu Jin Cho),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
Abstract |
The general use of a number of Tc-99m-labelled
compounds makes the need for good routine quality
control procedures, especially the labelling efficiency
measurements. The purpose of these study were to
measure the labelling efficiency of Tc-99m-labelled
MDP, DTPA, Tin colloid, and Antimony sulfide colloid
using miniaturized paper and instant thin layer
chromatography. The chromatographic systems include
whatman 3 MM paper and acetone, Gelman ITLC-SG and 0.9%
sodium chloride. The chromatographic strips are
miniaturized (1¡¿10 cm), marked and numbered.
Labelling efficiencies of Tc-99m-labelled DTPA and Tin
colloid were above 98.0%. Tc-99m- labelled Antimony
sulfide colloid was 90.0%. And labelling efficiency of
Tc-99m-labelled MDP was 89.0% Coefficient variance of
Tc-99m-labelled MDP, DTPA, Tin colloid, and Antimony
sulfide colloid were 5.14%, 2.06%, 1.82% and 4.90%,
respectively. We found that this miniaturized
chromatographic quality control was simple and
reliable. |