대한핵의학회지 (1967년~2009년)
대한핵의학회지 1990;24(1)133~5
원저 : Miniaturized Chromatography에 의한 99mTc - 표지 방사성의약품의 정도 관리 ( Miniaturized Chromatographic Quality Control of 99mTc Radiopharmaceuticals )
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Author 염미경(Mi Kyoung Yeom),정재민(Jae Min Jeong),진광호(Kwang Ho Jin),조규진(Kyu Jin Cho),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh),
Affiliation
Abstract

The general use of a number of Tc-99m-labelled compounds makes the need for good routine quality control procedures, especially the labelling efficiency measurements. The purpose of these study were to measure the labelling efficiency of Tc-99m-labelled MDP, DTPA, Tin colloid, and Antimony sulfide colloid using miniaturized paper and instant thin layer chromatography. The chromatographic systems include whatman 3 MM paper and acetone, Gelman ITLC-SG and 0.9% sodium chloride. The chromatographic strips are miniaturized (1¡¿10 cm), marked and numbered. Labelling efficiencies of Tc-99m-labelled DTPA and Tin colloid were above 98.0%. Tc-99m- labelled Antimony sulfide colloid was 90.0%. And labelling efficiency of Tc-99m-labelled MDP was 89.0% Coefficient variance of Tc-99m-labelled MDP, DTPA, Tin colloid, and Antimony sulfide colloid were 5.14%, 2.06%, 1.82% and 4.90%, respectively. We found that this miniaturized chromatographic quality control was simple and reliable.

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