원저 : 뇌의 Thyrotropin Releasing Hormone수용체 분포에 관한 연구 ( Characterization of Thyrotrpin releasing Hormone Receptor in Brain )
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| Author |
궁성수(Sung Soo Koong),김승택(Seung Taik Kim),정준기(June Key Chung),이명철(Myung Chul Lee),조보연(Bo Youn Cho),고창순(Chang Soon Koh),유은숙(Eun Sook Yoo),박은미(Eun Mey Park),서일택(Il Tak Seo), |
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| Abstract |
To evaluate the utility of autoradiographic technique
in the detection of TRH receptor changes in brain after
the various kinds of stimulation or drug
administration, we tried the characterization of TRH
receptor in mouse brain and autoradiography in rat
brain as a preliminary study. The Kd value of [3-H]
MeTRH to TRH receptors of adult male ICR mouse brain
(cebellum and spina1 cord were excluded) was 3.55+0.6
nM and Bmax was 3.44+0.52 fmol/mg wet tissue by
saturation analysis. The Kd value of TRH to TRH
receptors was 133.8+28.2 nM by competition analysis.
And we could visualize the distrbution of TRH receptors
in rat brain by autoradiographic technique. |
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| Full text Article |
28500971.pdf 
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