Abstract |
Irradiation is widely used for the treatment of
malignant diseases, and possibly cause the
osteoporosis. The densitometry and bone scintigraphy
are valuable when used to monitor the patients
longitudinally to access the progression of
osteoporosis and risk of osteoradionecrosis. To
evaluate the osteoporosis after irradiation of Cobalt-
60 gamma ray on the lumbar spines of New Zealand white
rabbits, bone densitometry by dual photon
absorptiometry and bone scintigraphy were perfomed
weekly. The decrease of bone density began at the first
week after irradiation, and were in the nadir at 4-6th
week. The osteoblastic activity measured by bone
scintigraphy decreased in the first week, and was in
the nadir at 4-6th week. The severity of these changes
were related to the radiation dose. In conclusion, the
osteoporosis before the presentation of the
osteoradionecrosis can be diagnosed early with the dual
photon absorptionmetry and bone scintigraphy. |