대한핵의학회지 (1967년~2009년)
대한핵의학회지 1990;24(2)317~8
원저 : 방사성동위원소표지 Liposome의 분포에 대한 실험적 연구 ( Distribution of Radionuclide Labeled Liposome in Experimental Study )
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Author 이범우(Bum Woo Lee),정재민(Jae Min Jeong),김상은(Sang Eun Kim),이동수(Dong Soo Lee),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh),하성환(Sung Whan Ha),
Affiliation
Abstract

Liposome was labelled with Tc-99m after negative charged liposome was formed with combination of a few lipid components. Tc-99m liposome was injected through the tail vein of C3H mice bearing fibrosarcoma and biodistribution of Tc-99m liposome was evaluated. The results were as follows: 1) We confirmed formation of liposome which was small unillamellar and multilamellar vesicles. 2) In this experiment the optimal concentration of SnCl2 was 156μg/ml to label liposome with Tc-99m SnCl2 labelling efficiency was 98%. 3) The labelled liposome was stable when it was incubated with human serum for 24 hours. Mean labelling efficiency was 94% at 24 hour. 4) The main uptake sites of Tc-99m liposome were liver and spleen. It showed significantly higher uptake than Tc-99m HSA (p〈0.001). 5) Tc-99m liposome uptake in tumor tissue was not significantly higher than Tc-99m HSA uptake. In conclusion,Tc-99m liposome disclosed high labelling efficiency and was highly stable. Liver and spleen were main uptake sites of Tc-99m liposome. The uptake mechanism of Tc-99m liposome also seemed to be different from that of Tc- 99m HSA. We conclude that Tc-99m liposome would be a promising agents for the imaging of some tumor.

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