Author |
김광원(Gwang Weon Kim),최정일(Chung Il Choi),정병천(Byung Cheon Chung),이재태(Jae Tae Lee),이규보(Kyu Bo Lee),채성철(Shung Chull Chae),전재은(Jae Eun Jun),박의현(Wee Hyun Park),박희명(Hee Myung Park), |
Abstract |
Thirty-one patients with coronary artery disease and
twenty-six normal subjects underwent 99mTc-GBPS before
and aft.er coronary vasodilatation was induced by
dipyridamIe 0.54 mg/kg given IV over 4 min. LVKF, EF
and regional wall motion by phase analysis were
measured during rest and dipyridamole infusion. The
results were as follows: 1) Mean LVEF of normal
subjects was significantly higher than that of MI group
(p=0.001), but similar to that of angina group during
rest. Among Ml group, mean LVEF of anterior MI group
was significantly lower than that of inferior MI group
during rest (p=0,024). 2) The normal subjects had a
significnat increase in mean LVEF during dipyridamole
infusion (+ 12 +- 3,8), while the CAD group had no
increase (+ 2=5.0) (p<0.001). If an increase of LVEF
during stress is less than 5%., it suggests an
abnormality. The sensitivity and specificity of LUEF
changes aft:er dipyridamole infusion were 81%, 96%,
respectively. 3) With phase analysis, LV mean phase
angle af normal subjects and CAD patients was 143+20,
5, 132 +- 20.6 rc.spectively, durign rest (p=0.049).
But an ncrease of LV mean phase angle during
dipyridamole infusion in t.hese two groups was not
signifieantly different. Dipyridarnole infusion did not
affect standard deviation and FWHM of phase angle. 4)
Regional wall motion was abnormal in 5 patients (16%)
during dipyridamole infusion. 5) Side effects with
dipyridamole infusion include; headache, angina pain,
chest discomfirt, nausea, weakness sense. In
conclusion, dipyridamole GBPS might be useful in
detection and follow up of CAD. |