Author |
김덕윤(Deog Yoon Kim),김상은(Sang Eun Kim),이동수(Dong Su Lee),안규리(Cu Rie Ahn),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
Abstract |
The purpose of this study is to investigate the ability
of I-131 labeled polyclonal human immunoglobulin to
localize an infection. In our country, indium-111
labeled leukocyte or Tc-99m labeled IgG are not readily
available because of compex, time-consuming procedure
and cost. So we tried to localize infection with I-131
labeled IgG which could be easily prepared. Six rats,
infected with staphylococcus aureus in a thigh muscle,
received I-131 labeled IgG intravenously and I-131
labeled bovine serum albumin (BSA) were injected to
other 5 infected rats. Scintigrams were made at 1, 4,
24, 48, 72 hour later. The radiopharmaceutical
demonstrated significant accumulation at the site of
infection. The accumulation of I-131 labeled IgG at the
site of infection was significantiy (P<0.05) higher
than that of I-131 labeled BSA at 48, 72 hour. Similar
finding could be found at 24 hour imaging, but it was
not significant statistically. Therefore it was found
that vascular permeability alone could not account for
the mode of action of I-131 labeled IgG and it was
considered that specific binding played a role. In
conclusion, focal sites of inAammation can be detected
with I-131 labeled nonspecific human polyclonal IgG and
it seems that this method can also be applied to
localization of human infection. |