대한핵의학회지 (1967년~2009년)
대한핵의학회지 1992;26(1)116~8
원저 : 123I , 99mTc 사람 비특이 IgG 및 67Ga - Citrate의 실험동물에서 염증병소 섭취율의 비교 ( Distribution of 123I , 99mTc - Human Polyclonal Nonspecific IgG and 67Ga - Citrate in Abscess bearing Mice )
()
Author 임상무(Sang Moo Lim),우광선(Kwang Sun Woo),정위섭(Wee Sup Chung),오옥두(Ok Doo Awh),서용섭(Yong Sup Seo),이종두(Jong Doo Lee),
Affiliation
Abstract

123I has ideal half life of 13 hours, suitable 159 keV gamma energy for imaging, and easy labeling methods. In Korea Cancer Center Hospital, 123I has been produced by MC-50 cyclotron. The purpose of this study is looking for good labeling condition of 123I and 99mTc to nonspecific human polyclonal IgG, and comparing these with 67Ga-citrate in the abscess bearing mice. Human polyclonal nonspecific IgG was labeled with 0.2 M phosphate buffer added 123I by chloramine T method. Human polyclonal nonspecific IgG was labeled with 99mTc-gluconate after activation with β- mercaptoethanol. In the abscess bearing mice, the radioactivity in the abscess was higher in 24 hours than 6 hours after injection. In the abscess, 123I nonspecific IgG had higher uptake than 99mTc-IgG or 67Ga-citrate. There was no significant difference in absecess uptake of 123I-IgG among 24, 72, 120 hours abscess age. Further clinical researches with 123I- nonspecific IgG, and other immunoscintigraphies using 123I are expected.

Keyword
Full text Article 28501165.pdf 28501165.pdf
(03121)서울시 종로구 지봉로 29 금호팔레스빌딩 1705호
TEL : 02-745-2040 FAX : 02-745-3833 E-mail : ksnm@ksnm.or.kr
Copyright 2012 by The Korean Society of Nuclear Medicine(KSNM)