원저 : 123I , 99mTc 사람 비특이 IgG 및 67Ga - Citrate의 실험동물에서 염증병소 섭취율의 비교 ( Distribution of 123I , 99mTc - Human Polyclonal Nonspecific IgG and 67Ga - Citrate in Abscess bearing Mice ) () |
Author |
임상무(Sang Moo Lim),우광선(Kwang Sun Woo),정위섭(Wee Sup Chung),오옥두(Ok Doo Awh),서용섭(Yong Sup Seo),이종두(Jong Doo Lee), |
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Abstract |
123I has ideal half life of 13 hours, suitable 159 keV
gamma energy for imaging, and easy labeling methods. In
Korea Cancer Center Hospital, 123I has been produced by
MC-50 cyclotron. The purpose of this study is looking
for good labeling condition of 123I and 99mTc to
nonspecific human polyclonal IgG, and comparing these
with 67Ga-citrate in the abscess bearing mice. Human
polyclonal nonspecific IgG was labeled with 0.2 M
phosphate buffer added 123I by chloramine T method.
Human polyclonal nonspecific IgG was labeled with
99mTc-gluconate after activation with β-
mercaptoethanol. In the abscess bearing mice, the
radioactivity in the abscess was higher in 24 hours
than 6 hours after injection. In the abscess, 123I
nonspecific IgG had higher uptake than 99mTc-IgG or
67Ga-citrate. There was no significant difference in
absecess uptake of 123I-IgG among 24, 72, 120 hours
abscess age. Further clinical researches with 123I-
nonspecific IgG, and other immunoscintigraphies using
123I are expected. |
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Full text Article |
28501165.pdf
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