대한핵의학회지 (1967년~2009년)
대한핵의학회지 1992;26(1)124~3
원저 : 비장동맥에 선택적으로 투여한 Interleukin - 2 화 99mTc - Phytate 혼합물의 생체내 분포 ( The in Vivo Distribution of 99mTc - Phytate IL - 2 Complex on Selective Splenic Arterial Injection )
()
Author 전석길(Seok Kil Zeon),이희정(Hee Jung Lee),손수상(Soo Sang Sohn),
Affiliation
Abstract

Colloidal 32P chromic phosphate is used to prevent hepatic metastasis from colorectal cancer. It is speculated that the intravenous injection of colloidal 32P chromic phosphate can cause genotoxicity. To evaluate the genotoxicity of intravenously injected colloidal 32P chromic phosphate, authors performed a micronuclei test in mice bone marrow. Mice(ICR strain, 25∼30 g) were divided to 4 groups: control, group 1 (19.166 KBq/g, usual therapeutic dose in human), group 2 (191.66 KBq/g), and group 3 (1916.6 KBq/g). Five mice of each group were sacrificed at days 1, 2, 3, 5, 7 and 14. Bone marrow were smeared and stained with Wright-Giemsa method. One thousand polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) were counted under the light microscope, and the number of micronucleated PCEs and NCEs were recorded. The frequency of micronuclei in PCE and NCE in the control group was 0.3±0.06% and 0.45±0.10%, respectively. At group 1, frequency of micronuclei is not different from the control. However, frequencies of micronuclei in PCE at groups 2 and 3 were significantly increased from day 1 and persisted to day 14. The frequency of micronuclei in NCE was increased only at group 3. In conclusion, the frequency of micronuclei increases as the dose of colloidal 32P chromic phosphate increases, while micronuclei was not induced at the usual therapeutic dose. And the frequency of micronuclei persistently elevated for 14 days in the cases of higer doses.

Keyword
Full text Article 28501166.pdf 28501166.pdf
(03121)서울시 종로구 지봉로 29 금호팔레스빌딩 1705호
TEL : 02-745-2040 FAX : 02-745-3833 E-mail : ksnm@ksnm.or.kr
Copyright 2012 by The Korean Society of Nuclear Medicine(KSNM)