원저 : 마우스에서 경구투여한 방사성스트론튬의 제거에 대한 경구투여 카이토산과 알긴산의 효과 ( Effect of Oral Ingestion of Chitosan and Alginate on the Removal of Orally Ingested Radiostrontium ( 86Sr ) in Mice ) () |
Author |
김희경(Hee Kyung Kim),김광윤(Kwang Yoon Kim),범희승(Hee Seung Bom),최근희(Keun Hee Choi),김지열(Ji Yeul Kim), |
|
Affiliation |
|
Abstract |
Radiostrontium is one of fallouts. It can be absorbed
through intestine and causing radiation injury to
bones. The purpose of this study is to evaluate the
inhibitory effect of 10% chitosan (water soluble and
insoluble) and 10% alginate (water soluble and
insoluble) on radiostrontium adsorption. Water soluble
and insoluble chitosans and alginates were given to 10
NIH male mice in each group for 7 days. At the 7th day,
74 MBq of 85Sr were given through orogastric tube.
Chitosans and alginates were given for additional 7
days. During the 7 days, radioactivities of feces were
counted daily. Finally animals were sacrificed, and
radioactivities of bones were counted. Feca1 excretion
was significantly higher in chitosan and alginate group
as compared to control from the lst day (p〈0.01).
Water soluble chitosan group showed highest fecal
excretion. Bony retention was significantly lower in
the treated group than the control (p〈0.01). There was
no difference among treated groups. In conclusion, both
water soluble and insoluble chitosans and alginates
were effective agents on lowering orally ingested
radiostrontium (85Sr) |
Keyword |
Chitosan, Alginate, Radiostrontium |
Full text Article |
28501288.pdf
|
|
|