대한핵의학회지 (1967년~2009년)
대한핵의학회지 1993;27(2)203~7
원저 : Dipyridamole 부하 심근 SPECT에서 Dipyridamole의 작용과 부작용 ( The Effect and Side Effect of Dipyridamole in Myocardial SPECT )
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Author 양형인(Hyung In Yang),이동수(Dong Soo Lee),여정석(Jeong Suk Yeo),배상균(Sang Kyun Bae),최창운(Chang Woon Choi),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh),
Affiliation
Abstract

Dipyridamole is an agent that may be used to noninvasively evaluate coronary artery disease. The effect of dipyridamole infusion its generally related to its induced peripheral vasodilatory effect. In normal person, heart rate is generally increased slightly while blood pressure decrease, but the achieved double product and related myocardial oxygen consumption have no significant change. The purpose of this study is to examine the effect and side effect of dipyridamole, and to compare different response to dipyridamole among the patients. We evaluated 847 patients who underwent dipyridamole stress myocardial SPECT. 93.6% of them had induced hypotension 0.9% showed no change of blood pressure, 5.5% had increased blood pressure 8.3% had no change of pulse rate more than 10% of basal pulse rate. Among diabetes, 16.9% was not change of pulse rate, 6.7% in non-diabetes. There was no significant correlation between age and rate pressure product rest(RPPr), in patients without perfusion defects on SPECT(y=7.1x+48.4r=0.13 p>0.01). As increasing age, RPPs/RPPr was declined(y=-11.6x+68.9 r=0.17 p〈0.01), similar results were obtained in patients with perfusion defect. The size of perfusion defect on myocardial SPECT have no correlation between RPPr and RPPs/RPPr. The side effects of dipyridamole included chest pain and chest tightness, headache, abdominal pain, dizzness, nausea, and dyspnea. As increasing age, dipyridamole-induced cardiac work at rest was increased, cardiac response to dipyridamole was decreased.

Keyword Dipyridamole, Myocardial SPECT, Pulse pressure product
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