Author |
양형인(Hyung In Yang),이동수(Dong Soo Lee),여정석(Jeong Suk Yeo),배상균(Sang Kyun Bae),최창운(Chang Woon Choi),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
Abstract |
Dipyridamole is an agent that may be used to
noninvasively evaluate coronary artery disease. The
effect of dipyridamole infusion its generally related
to its induced peripheral vasodilatory effect. In
normal person, heart rate is generally increased
slightly while blood pressure decrease, but the
achieved double product and related myocardial oxygen
consumption have no significant change. The purpose of
this study is to examine the effect and side effect of
dipyridamole, and to compare different response to
dipyridamole among the patients. We evaluated 847
patients who underwent dipyridamole stress myocardial
SPECT. 93.6% of them had induced hypotension 0.9%
showed no change of blood pressure, 5.5% had increased
blood pressure 8.3% had no change of pulse rate more
than 10% of basal pulse rate. Among diabetes, 16.9% was
not change of pulse rate, 6.7% in non-diabetes. There
was no significant correlation between age and rate
pressure product rest(RPPr), in patients without
perfusion defects on SPECT(y=7.1x+48.4r=0.13 p>0.01).
As increasing age, RPPs/RPPr was declined(y=-11.6x+68.9
r=0.17 p〈0.01), similar results were obtained in
patients with perfusion defect. The size of perfusion
defect on myocardial SPECT have no correlation between
RPPr and RPPs/RPPr. The side effects of dipyridamole
included chest pain and chest tightness, headache,
abdominal pain, dizzness, nausea, and dyspnea. As
increasing age, dipyridamole-induced cardiac work at
rest was increased, cardiac response to dipyridamole
was decreased. |