원저 : < 51Cr > Cr ( III )-EDTA 착물 합성 및 < 51Cr > Cr ( III )-EDTA 주사후 두경부 방사능 계측에 의한 사구체 여과율 측정 ( Synthesis of < 51Cr > Cr ( III )-EDTA Complex and Measurement of Glomerular Filtration Rate by Radioactivity Counting of Head and N () |
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양승대 , 임상무 , 전권수 , 서용섭 , 윤용기 , 박현 , 우광선 , 정위섭 , 오옥두 , 이종두 ( Seung Dae Yang , Sang Moo Lim , Kwon Soo Chun , Yong Sup Suh , Yong Ki Yoon , Hyun Park , Kwang Sun Woo , Wi Sup Chung , Jong Doo Lee , Ok Doo Oh ), |
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Abstract |
The purpose of this study is to evaluate the clinical application of the no carrier added[Cr] Cr(UI) EDTA complexes, produced at Korea Cancer Center Hospital. The [Cr]Cr(lll) EDTA complexes, useful for measurement of GFR were prepared at room temperature in the presence of bicarbonate catalysts. The radiochemical purity of[Cr]Cr (Iil) EDTA was over 99% by paper electrophoresis. The time activity curves were obtained by counting the blood samples from 5 volunteers and counting the head and neck regions with whole body counter after inject#ion of the Cr EBTA, respectively, After the nonlinear regression, the area under curve was obtained. The plasma clearance of the Cr-EDTA was calculated with injected dose/AUC. The clearance rate calculated with the head and neck countmg data was in good agreement with t,he result from the plasma sample radioactivity at, 1-3 hrs after injection. From this result, the counting of head and neck region and the nonlinear regression by 2-compartment model could be applied for the measurement of the clearance rate. Using MIRD system, the absorbed radiation dose was calculated by residence time x S. The absorbed whole body radiation dose was negligibly small. |
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