Abstract |
Medicai Internal Radiation Dose(MIRD) schema was
developed for calculating the absorbed dose from the
administered radiopharmaceuticals. With the biological
distribution data and the physical properties of the
radionuclide we can estimate the absorbed dose by the
MIRD schema. For the thyroid cancer patients received
131I therapy, the absorbed dose to the bone marrow is
the limiting factor to the administered dose, and the
duration of admission is determined by the retained
activity in the whole body. To monitor the whole body
radioactivity, we used Eberline Smart 200 system using
ionization chamber as a detector. With the time
activity curve of the whole body, total body residence
time was obtained. From the ICRP publication 53, the
residence times of the source organs, such as kidney,
urinary bladder content and stomach, were, used to
calculate the absorbed doses of the target organs, such
as stomach, red marrow, b1adder wall and remaineder
total body. In 8 thyroid cancer patients with 175 mci
of 131I adminstered orally, the mean absorbed dose in
the blader wall was 375.1 in the stomach 285.1, red
marrow 25.4 and total body 22.4 rad respectively. For
the monitoring of the large administered activity, this
method seemed to be quite useful. |