대한핵의학회지 (1967년~2009년)
대한핵의학회지 1995;29(4)484~8
원저 : 99mTc - DISIDA 신티그래피를 이용한 간세포암 간외 전이의 진단 : 원발 간세포암과의 비교 ( 99mTc - DISIDA Scintigraphic Diagnosis of Extrahepatic Hepatocellular Carcinoma Metastasis : Comparison with Primary Hepatocellular carcinoma )
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Author 정수교(Soo Kyo Chung),김성훈(Sung Hoon Kim),백준현(Joon Hyun Baik),김영주(Young Joo Kim),천경아(Kyung Ah Chun),박석희(Seog Hee Park),박용휘(Yong Whee Bahk),신경섭(Kyung Sub Shin),
Affiliation
Abstract

It is well known that hepatobiliary agent are taken up by metastatic hepatocellular carcinoma(HCC) as well as primary HCC. But the reported cases of the extrahepatic metastasis of HCC diagnosed by hepatobiliary scintigraphy are for the most part hematogenous ones. The relation of the uptake pattern of hepatobiliary agent in the primary and metastatic HCC is also still remains unknown. So we undertook this study to evaluate the relation of the hepatobiliary scintigraphic patterns of primary and metastatic HCC with different metastiatic routes. Nine patients with primary HCC and twelve cases of metastaic HCC including four lung metastases, one bone metastasis, one right atrial metastasis, one peritoneal wall metastasis, and five lymph node metastases were studied with Tc-99m-DISIDA scintigraphy. The images were taken on 10, 30 minutes, 1, 2, 4-6 hours. The overall detection rates of hematogenous metastases(lung and bone) is 60%(3 of 5), direct metastasis(right atrium and peritoneal wall), 100%(2 of 2) and lymphatic metastases, 0%(0 of 5). In four of five metastatic cases demonstrated with hepatobiliary scintigraphy, biliary agent is also taken up by primary HCC lesions. And the appearing time of the radioactivity in the direct metastatic HCC lesion is same as that of primary HCC and in the cases of hematogenous metastasis, earlier than that of primary HCC. Hepatobiliary scintigraphy is more useful in the diagnosis of the metastatic HCC than primary HCC, in the cases of hematogenous and direct metastasis.

Keyword 99mTc-DISIDA, Hepatobiliary scintigraphy. Metastases of hepatocellular carcinoma
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