원저 : [ I - 123 ] IPT SPECT를 이용한 도파민 재섭취부위의 영상화 : 반정성적 분석방법을 이용한 정상인과 파킨슨병 환자의 차이 ( [ I - 123 ] IPT SPECT Dopamine Reuptake Site Imaging : Differences in Normal Controls and parkinson ` s Patients by Semiquantitat () |
Author |
김희중(Hee Joung Kim),임주혁(Joo Hyuck Im),양승오(Seoung Oh Yang),류진숙(Jin Sook Ryu),최윤영(Yun Young Choi),이명종(Myung Chong Lee),이희경(Hee Kyung Lee), |
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Affiliation |
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Abstract |
Dopamine transporter concentrations have been known to
decrease in Parkinson's disease (PD) or increase in
Tourette's disorder. The purpose of this study was to
evaluate the effectiveness of [I-123]N-(3-iodopropene-
2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane
(IPT) as an imaging agent for measuring changes in
transporter concentrations with PD. IPT labelled with
6.69+/-0.64 mCi (247.53+/-23.68 MBq) of I-123 was
intravenously injected into ten patients(age: 55+/-11)
with PD, and six normal controls(NC)(age: 46+/-14) as a
bolus. Dynamic SPECT scans of the brain were then
performed for 5 minutes each over 120 minutes on a
triple headed camera. Time activity curves were
generated for the left basal ganglia(LBG), right basal
ganglia(RBG), and occipital cortex(OCC). The
statistical parameters included the time to peak
activity, the contrast ratio of LEG and RBG to OCC at
several time points, and the accumulated specific
binding counts/mCi/pixel (ASBC) from 0 to 115 minutes.
The uptake of IPT in the brains of PD and NC peaked
within 10 minutes of injection in all subjects. The
maximum target to background ratio in the basal ganglia
of PD and NC occurred at 85+/-20 min and 110-+/-6 min
of injection, respectively. The BG/OCC ratios at 115
minutes for PD and NC were 2.15+/-0.54 and 4.26+/-0.73,
respectively. The ASBC at 115 minutes for PD and NC
were 152.91+/-50.09 and 289.51+/-49.00, respectively.
The ratio of BG/OCC for the NC was significantly higher
than the ratio for PD. SPECT data matched with clinical
diagnosis for PDs. The ratio between BG and OCC and the
ASBC for PD were clearly separated from NC and may be
useful outcome measures for clinical diagnosis. The
findings suggest that IPT may be a very useful tracer
for early diagnosis of PD and study of dopamine
reuptake site. |
Keyword |
IPT, SPECT, Dopamine transporter, Parkinson`s patients |
Full text Article |
28501621.pdf
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