원저 : [ I - 123 ] IPT SPECt를 이용한 정상인과 파킨슨환자의 도파민 운반체의 영상화 및 단순화된 정량분석 방법들의 비교연구 ( A Study of Dopamine Transporter Imaging and Comparison of Noninvasive Simplified Quantitative Methods in Normal Controls and Parkin () |
Author |
봉정균(Jung Kyun Bong),김희중(Hee Joung Kim),임주혁(Joo Hyuck Im),양승오(Seoung Oh Yang),문대혁(Dae Hyuk Moon),류진숙(Jin Sook Ryu),남기표(Ki Pyo Nam),천준홍(Jun Hong Cheon),권수일(Soo Il Kwon),이희경(Hee Kyung Lee), |
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Affiliation |
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Abstract |
The purpose of this study was to compare the specific
binding ratio method with model based methods in
estimating the transporter parameter k3/k4 in normal
controls and Parkinson's patients with [I-123]IPT SPECT
and to evaluate the usefulness of [I-123]IPT SPECT.
6.5¡¾1.1 mCi (239.0¡¾40.3 MBq) of [123]IPT was
intravenouly injected as a bolus into six normal
controls(age:45¡¾13) and seventeen
patients(age:55¡¾8) with Pakinson's disease(PD). The
transporter parameter k3/k4 was derived using the
Ichise's graphical method(Rv) and Lassen's area ratio
method(RA) for the dynamic IPT SPECT data without blood
samples. Then, the relationships between the
transporter parameter Rv, RA and the ratio of (BG-
OCC)/OCC at 115 minutes were evaluated by linear
regression analysis. Rvs by Ichise's graphical method
for NC and PD were 2.08¡¾0.29 and 0.78¡¾0.31,
respectively. RAs by Lassen's area ratio method for NC
and PD were 1.48¡¾0.16 and 0.65¡¾0.24,
respectively. The correlation coefficients between (BG-
OCC)/OCC and Rv, (BG-OCC)/OCC and RA, and RV, and RA
were 0.93, 0.90, 0.99 and their corresponding slopes
were 0.54, 0.34, and 0.65,respectively. The Rv and RA
of NC were significantly higher than the ones of PD.
That is, the k3/k4 Of NC was clearly separated from the
one of PD. k3/k4 showed a good correlation with the
ratio of (BG-OCC)/OCC. The results indicate that the
noninvasive simplified quantitative methods may be
useful to measure the transporter parameter k3/k4 and
the specific binding ratio method can be used for
quantitative studies of dopamine transporter with [I-
123]IPT SPECT in humans brains. |
Keyword |
Dementia, Alzheimer`s disease, Cognitive impairment, Positron emission tamography, Ratio analysis 28501758Key Words: IPT, SPECT, Dopamine transporter, Specific binding ratio mcthod, Graphical method, Area ratio method |
Full text Article |
28501758.pdf
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