대한핵의학회지 (1967년~2009년)
대한핵의학회지 1996;30(3)315~10
원저 : [ I - 123 ] IPT SPECt를 이용한 정상인과 파킨슨환자의 도파민 운반체의 영상화 및 단순화된 정량분석 방법들의 비교연구 ( A Study of Dopamine Transporter Imaging and Comparison of Noninvasive Simplified Quantitative Methods in Normal Controls and Parkin
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Author 봉정균(Jung Kyun Bong),김희중(Hee Joung Kim),임주혁(Joo Hyuck Im),양승오(Seoung Oh Yang),문대혁(Dae Hyuk Moon),류진숙(Jin Sook Ryu),남기표(Ki Pyo Nam),천준홍(Jun Hong Cheon),권수일(Soo Il Kwon),이희경(Hee Kyung Lee),
Affiliation
Abstract

The purpose of this study was to compare the specific binding ratio method with model based methods in estimating the transporter parameter k3/k4 in normal controls and Parkinson's patients with [I-123]IPT SPECT and to evaluate the usefulness of [I-123]IPT SPECT. 6.5¡¾1.1 mCi (239.0¡¾40.3 MBq) of [123]IPT was intravenouly injected as a bolus into six normal controls(age:45¡¾13) and seventeen patients(age:55¡¾8) with Pakinson's disease(PD). The transporter parameter k3/k4 was derived using the Ichise's graphical method(Rv) and Lassen's area ratio method(RA) for the dynamic IPT SPECT data without blood samples. Then, the relationships between the transporter parameter Rv, RA and the ratio of (BG- OCC)/OCC at 115 minutes were evaluated by linear regression analysis. Rvs by Ichise's graphical method for NC and PD were 2.08¡¾0.29 and 0.78¡¾0.31, respectively. RAs by Lassen's area ratio method for NC and PD were 1.48¡¾0.16 and 0.65¡¾0.24, respectively. The correlation coefficients between (BG- OCC)/OCC and Rv, (BG-OCC)/OCC and RA, and RV, and RA were 0.93, 0.90, 0.99 and their corresponding slopes were 0.54, 0.34, and 0.65,respectively. The Rv and RA of NC were significantly higher than the ones of PD. That is, the k3/k4 Of NC was clearly separated from the one of PD. k3/k4 showed a good correlation with the ratio of (BG-OCC)/OCC. The results indicate that the noninvasive simplified quantitative methods may be useful to measure the transporter parameter k3/k4 and the specific binding ratio method can be used for quantitative studies of dopamine transporter with [I- 123]IPT SPECT in humans brains.

Keyword Dementia, Alzheimer`s disease, Cognitive impairment, Positron emission tamography, Ratio analysis 28501758Key Words: IPT, SPECT, Dopamine transporter, Specific binding ratio mcthod, Graphical method, Area ratio method
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