Author |
신중우(Jung Woo Shin),류진숙(Jin Sook Ryu),원경숙(Kyoung Sook Won),최윤영(Yun Young Choi),김희중(Hee Jung Kim),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),서용섭(Yong Sup Suh), |
Abstract |
The purpose of this study was to evaluate the clinical
usefulness of I-123 MIBG scintigraphy with early planar
and SPECT image in the diagnosis of neuroendocrine
tumors. We reviewed I-123 MIBG scintigraphies of 21
patients who had been suspected to have neuroendocrine
tumors by CT or MRI findings. Early 4 hour planar and
SPECT images were obtained in all patients and delayed
(13-24 hour) planar images were performed in 17
patients. Final diagnoses were made by surgery, biopsy,
or clinical follow up. Twelve patients were confirmed
to have neuroendocrine tumors. With 4 hour planar and
SPECT images, there were 9 true positives(6
pheochromocytomas, 1 paraganglioma, 1 neuroblastoma,
and 1 medullary cancer of the thyroid), 8 true
negatives(l adrenal cortical adenoma, 1 malignant
fibrous histiocytoma, 1 adenoma in colon and 5 benign
nonfunctioning adrenal tumors), l false
positive(hepatocellular carcinoma) and 3 false
negatives(l recurred medullary cancer of the thyroid, 1
liver metastasis of carcinoid tumor and 1
ganglioneuroma). The sensitivity and specificity of I-
123 MIBG scintigraphy were 75% and 89%, respectively.
SPECT images provided good anatomical correlation with
CT or MRI. Delayed images showed increased tumor to
background ratio in 5 out of 8 true positive patients,
but did not change the diagnosis. In conclusion, early
4 hour images with I-123 MIBG is clinically convenient
and useful method in the detection of neuroendocrine
tumors, and SPECT images can provide good anatomical
correlation with CT or MRI. |