원저 : N - 13 암모니아와 양전자방출단층촬영 동적영상을 이용하여 심근혈류량을 정량화하는 새로운 방법 개발에 관한 연구 ( A Refined Method for Quantification of Myocardial Blood Flow using N - 13 Ammonia and Dynamic PET ) () |
Author |
김준영(Joon Young Kim),최용(Yearn Seong Choe),이경한(Kyung Han Lee),김상은(Sang Eun Kim),최연성(Yong Choi),주희경(Hee Kyung Ju),김영진(Yong Jin Kim), 김병태(Byung Tae Kim), |
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Affiliation |
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Abstract |
Regional myocardial blood flow (rMBF) can be
noninvasively quantified using N-13 ammonia and dynamic
positron emission tomography (PET). The quantitative
accuracy of the rMBF values, however, is affected by
the distortion of myocardial PET images caused by
finite PET image resolution and cardiac motion.
Although different methods have been developed to
correct the distortion typically classified as partial
volume effect and spillover, the methods are too
complex to employ in a routine clinical environment. We
have developed a refined method incorporating a
geometric model of the volume representation of a
region-of-interest (ROI) into the two- compartment N-13
ammonia model. In the refined model, partial volume
effect and spillover are conveniently corrected by an
additional parameter in the mathematical model. To
examine the accuracy of this approach, studies were
performed in 9 coronary artery disease patients.
Dynamic transaxial images (16 frames) were acquired
with a GE AdvanceTM PET scanner simultaneous with
intravenous injection of 20 mCi N-13 ammonia. rMBF was
examined at rest and during pharmacologically
(dipyridamole) induced coronary hyperemia. Three
sectorial myocardium (septum, anterior wall and lateral
wall) and blood pool time-activity curves were
generated using dynamic images from manually drawn
ROIs. The accuracy of rMBF values estimated by the
refined method was examined by comparing to the values
estimated using the conventional two-compartment model
without partial volume effect correction. rMBF values
obtained by the refined method linearly correlated with
rMBF values obtained by the conventional method (108
myocardial segments, correlation coefficient (r)=0.88).
Additionally, underestimated rMBF values by the
conventional method due to partial volume effect were
corrected by theoretically predicted amount in the
refined method (slope(m)=1.57). Spillover fraction
estimated by the two methods agreed well (r=1.00,
m=0.98). In conclusion, accurate rMBF values can be
efficiently quantified by t |
Keyword |
positron emission tomography (PET), regional myocardial blood flow(rMBF). N-13 ammonia, partial volume effect, spillover |
Full text Article |
28502003.pdf
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