대한핵의학회지 (1967년~2009년)
대한핵의학회지 1997;31(1)83~7
원저 : CT상 악성여부가 불명확한 단일 폐결절에서의 양전자방출단층촬열술의 유용성 ( Role of PET in Evaluating Indeterminate Solitary Pulmonary Nodule with CT )
()
Author 윤석부(Seok Boo Yoon),김병태(Byung Tae Kim),최준영(Joon Young Choi),김선정(Sun Jung Kim),최용(Yong Choi),최연성(Yearn Seong Choe),이경한(Kyung Han Lee),김상은(Sang Eun Kim),권오정(O Jung Kwon),이경수(Kyung Soo Lee),
Affiliation
Abstract

About one-third of radiologically indeterminate solitary pulmonary nodules (SPN) are eventually turned out to be malignant. It is very important to noninvasively determine whether the SPN is malignant or not for the decision of its way of management. PET imaging is highlighted by its unique ability of imaging the function and metabolism of cells. Glucose metabolism is increased in malignant transformed cells. We performed FDG-PET studies in patients who ha radiologi- cally indeterminate SPN and compared the findings with histologic diagnoses to assess the diagnostic accuracy in the detection of malignancy and to decide which parameter is the most suitable for clinical practice among peak SUV (pSUV), average SUV (aSUV), 50/10 ratio, and time-activity curve (TAC). Thirty patients were included in this study and the most useful parameter was pSUV. The sensitivity and specificity in the detection of malignant SPN using 3.5 as a cut off pSUV were both 87%. Interestingly, all 2 false-negative cases were bronch- ioloalveolar carcinoma on histologic examination. If these cases, which could be strongly suspected by CT findings, were excluded, the sensitivity of pSUV was 100%. In conclusion, PET imaging is very helpful for determining malignancy in indeterminate SPN and pSUV is a conveniently measurable parameter which is valuable for interpretation.

Keyword Indeterminate solitary pulmonary nodule, Positron emission tomography, Peak standardized uptake value, Time-activity curve
Full text Article 28502004.pdf 28502004.pdf
(03121)서울시 종로구 지봉로 29 금호팔레스빌딩 1705호
TEL : 02-745-2040 FAX : 02-745-3833 E-mail : ksnm@ksnm.or.kr
Copyright 2012 by The Korean Society of Nuclear Medicine(KSNM)