원저 : CT상 악성여부가 불명확한 단일 폐결절에서의 양전자방출단층촬열술의 유용성 ( Role of PET in Evaluating Indeterminate Solitary Pulmonary Nodule with CT ) () |
Author |
윤석부(Seok Boo Yoon),김병태(Byung Tae Kim),최준영(Joon Young Choi),김선정(Sun Jung Kim),최용(Yong Choi),최연성(Yearn Seong Choe),이경한(Kyung Han Lee),김상은(Sang Eun Kim),권오정(O Jung Kwon),이경수(Kyung Soo Lee), |
|
Affiliation |
|
Abstract |
About one-third of radiologically indeterminate
solitary pulmonary nodules (SPN) are eventually turned
out to be malignant. It is very important to
noninvasively determine whether the SPN is malignant or
not for the decision of its way of management. PET
imaging is highlighted by its unique ability of imaging
the function and metabolism of cells. Glucose
metabolism is increased in malignant transformed cells.
We performed FDG-PET studies in patients who ha
radiologi- cally indeterminate SPN and compared the
findings with histologic diagnoses to assess the
diagnostic accuracy in the detection of malignancy and
to decide which parameter is the most suitable for
clinical practice among peak SUV (pSUV), average SUV
(aSUV), 50/10 ratio, and time-activity curve (TAC).
Thirty patients were included in this study and the
most useful parameter was pSUV. The sensitivity and
specificity in the detection of malignant SPN using 3.5
as a cut off pSUV were both 87%. Interestingly, all 2
false-negative cases were bronch- ioloalveolar
carcinoma on histologic examination. If these cases,
which could be strongly suspected by CT findings, were
excluded, the sensitivity of pSUV was 100%. In
conclusion, PET imaging is very helpful for determining
malignancy in indeterminate SPN and pSUV is a
conveniently measurable parameter which is valuable for
interpretation. |
Keyword |
Indeterminate solitary pulmonary nodule, Positron emission tomography, Peak standardized uptake value, Time-activity curve |
Full text Article |
28502004.pdf
|
|
|