Author |
김유경(Yu Kyeong Kim),정준기(Jung Key Chung),이동수(Dong Soo Lee),조보연(Bo Yeon Cho),정재민(Jae Min Jeong),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
Abstract |
To evaluate the effectiveness of I-131 in ablation of
residual thyroid tissue, we analyzed 350 patients with
thyroid cancer who were treated with various doses of
I-131 after surgery for thyroid cancer. Two hundred
fifty five patients were treated with l.lGBq(30mCi) of
I-131 for ablation of remnant thyroid and one hundred
seventeen patients received more than 2.8GBq(75mCi) of
I-131. We determined the effectiveness of ablation by
following I-131 whole body scan. Absent visible uptake
or minimal uptake in thyroid tissue were considered as
successful ablation. Of 255 patients who received doses
of 30mCi I-131 therapy, 131 patients(51%) showed
successful ablation of residual thyroid tissue with
2.6¡¾1.7 times of I-131 therapy. Of 117 patients who
received doses of the more than 75mCi I-131, 84
patients(72%) had successful remnant thyroid ablation
with 1.6¡¾1.1 times of I-131 therapy. According to
the extent of surgery, successful ablation rates were
78%, 62%, 54%, 33% in patients who underwent total
thyroidectomy, subtotal thyroidectomy, lobectomy and
isthmectomy, lobectomy or tumorectomy, respectively.
This study showed that ablation of remnant thyroid
after surgery with 30mCi I-131 was successful only in
50%. Therefore, in cases of patients with high risk for
recurrence, we recommend high dose I-131 for ablation
of remnant after total thyroidectomy. |