원저 : 수술 후 암 재발 판정에 있어서 전신 F - 18 FDG - PET의 유용성 ( The Usefulness of F - 18 FDG Whole Body PET in the Evaluation of Postoperative Recurrence of Cancer ) () |
Author |
강원준(Won Jun Kang),소영(Young So),정재민(Jae Min Jeong),곽철은(Cheol Eun Kwark),이동수(Dong Soo Lee),강순범(Soon Beum Kang),정희원(Hee Won Jung),김광현(Kwang Hyun Kim),박재갑(Jae Gahb Park),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
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Affiliation |
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Abstract |
he purpose of this study was to evaluate the usefulness
of whole body F-18 FDG PET scan for deceting
postoperative recurrence of cancer. One hundred four
cancer patients after operation were enrolled(l4 brain
tumor, 15 head and neck cancer, 23 gynecologic cancer).
Besides conventional images(CI) including CT and MRI,
F-18 FDG PET scan was obtained on ECAT EXACT 47
scanner(Siemens-CTI), beginning 60 minutes after
injection of 370MBq(10mCi) of F-18 FDG. Regional scan
was also obtained with emission image. Transmission
images using Ge-68 were carried out for attenuation
correction in both whole body and regional images.
Findings of PET and CI were confirmed by pathology or
clinical follow up. The sensitivity and specificity of
PET for detecting recurrence were 94% and 92%,
respectively. Contrarily, the sensitivity and specific
it of CI were 78% and 68% CI results were negative and
PET results were positive in 11 cases. The biopsy or
clinical follow-up of those cases confirmed recurrence
of tumor. False negative cases of CI were frequent in
patients with gynecologic cancers. Also we measured the
Serum concentration of tumor markers in patients with
gynecologic cancer(CA125), thyroid
cancer(thyroglobulin), and colorectal cancer(CEA). The
sensitivity and specificity of tumor markers were 71%
and 84%, respectively. We conclude that F-18 FDG PET
can be used valuably in detecting recurrent foci of a
wide variety of malignancy compared to conventional
diagnositic methods. |
Keyword |
PET, FDG, Cancer, Recurrence |
Full text Article |
28502020.pdf
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