원저 : 활동성 폐결핵의 판정에서 99mTc-MIBI 의 유용성 ( The Usefulness of 99mTc-MIBI in the Detection of Active Pulmonary Tuberculosis ) () |
Author |
이효진(Hyo Jin Lee),전두수(Doo Soo Cheon),유석동(Seok Dong Yoo),이민기(Min Ki Lee),박순규(Soon Kew Park),김성장(Seong Jang Kim),김인주(In Ju Kim),김용기(Yong Ki Kim), |
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Affiliation |
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Abstract |
The use of radiopharmaceuticals in evaluation of
pulmonary tuberculosis may help to resolve difficult
diagnostic problems such as discordance between sputum
examinations and chest roentgenographic findings. We
investigated the usefulness of 99mTc-
methoxyisobutylisonitrile(MIBI) scintigraphy in the
detection of active pulmonary tuberculosis. Forty-six
patients with suspected active pulmonary tuberculosis
were studied with sputum smear of AFB, sputum AFB
culture, chest X-ray and MIBI scan. MIBI image was
obtained 15 and 60 min after intravenous injection of
370MBq(10mCi) 99mTc-MIBI. In 16 patients of them Ga
scans were performed in addition to MIBI scan. Repeated
MIBI scans were done in 7 patients with active
pulmonary tuberculosis after 4∼6 months of
antituberculous chemotherapy. Thirty-two patients were
confirmed as active tuberculosis by sputum culture.
Sensitivity of MIBI scan to active tuberculosis was
87.5%(28/32) and MIBI findings were negative in all of
14 patients with inactive disease. Focal uptake of MIBI
was dense in the area that was strongly suggested
active tuberculous lesions by chest roentgenogram.
There was no discordance between MIBI and Ga image in
16 patients. But the uptake areas of Ga images were
broader than that of MIBI images. After 4∼6 months of
antituberculous treatment all repeated MIBI scans
revealed negative findings except 1 patient with
persistent active pulmonary tuberculosis due to drug
resistance. MIBI scan could be used in the detection of
active pulmonary tuberculosis as a useful noninvasive
diagnostic tool. |
Keyword |
Pulmonary tuberculosis; Tc-99m-MIBI; Infection imaging |
Full text Article |
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