원저 : 단일 폐병변에서 T1-201 SPECT 를 이용한 악성 종양의 감별진단 ( Thallium-201 SPECT in Differential Diagnosis of Malignancy from Benign Pathology in Patients with a Solitary Pulmonary Lesion ) () |
Author |
안병철(Byeong Cheol Ahn),이재태(Jae Tae Lee),천경아(Kyung Ah Chun),김동환(Dong Hwan Kim),손상균(Sang Kyun Sohn),김창호(Chang Ho Kim),박재용(Jae Yong Park),정태훈(Tae Hoon Jeong),이규보(Kyu Bo Lee),김천기(Chun K. Kim), |
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Affiliation |
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Abstract |
Purpose: T1-201 SPECT has been used in differentiating
benign and malignant pulmonary lesions. While its
sensitivity may be high, the specificity and predictive
values are reported to be variable depending on the
type of benign lung lesion. The purpose of this study
was to prospectively assess the efficacy of T1-201
SPECT for differentiating benign and malignant single
pulmonary lesions in a population with a high
prevalence of begin pulmonary lesions, especially,
tuberculosis. Materials and Methods: One-hundred
thirty-three patients, having 89 malignant and 44
benign lesions(23 active tuberculosis, 5 inactive
tuberculosis, 3 aspergilloma, 3 focal pneumonia, 2
thymoma, and 8 others), were imaged using a dual-headed
system at 15 minute(early) and 3 hour (delayed)
following administration of 111MBq T1-201. The images
were read visually and lesion-to-background ratios(L/B)
were obtained from transverse tomographic slices.
Retention index was expressed as [(delayed L/B-early
L/B) ¡À early L/B]. Results: 82/89(92%) and 83/89(93%)
of the malignant lesions were visually positive on the
early and delayed images, and 27/44(61%) and 26/44(59%)
of the benign lesions wefe also between the mean L/B's
of the malignant and benign lesions, L/B was not useful
for differentiating the two due to a large overlap.
There was no difference in retention indices.
Conclusion: Despite of its high sensitivity, the
specificity of T1-201 SPECT was unacceptably low in
patients with active benign lesions. The positive and
negative predictive values for lung cancer in a
population with a high prevalence of the benign single
pulmonary lesion was only marginal. |
Keyword |
Thallium-201 SPECT, Lung cancer |
Full text Article |
28502128.pdf
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