대한핵의학회지 (1967년~2009년)
대한핵의학회지 1998;32(3)290~8
원저 : 종양 이식 백서에서 3-<131I>iodo-O-methyl-L-alpha-methyltyrosine 의 체내 동태 연구 - L-3-<131I>iodo-alpha-methyltyrosine 와 비교 ( Biodistribution of 3-<131I>iodo-O-mythyl-L-alpha-methyltyrosine in Tumor Bearing Rats - A Comparison Study with L-3-<1
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Author 최창운 , 양승대 , 우광선 , 정위섭 , 임수정 , 서용섭 , 전권수 , 안순혁 , 이종두 , 홍성운 , 임상무 ( Chang Woon Choi , Seung Dae Yang , Kwang Sun Woo , Wee Sup Chung , Soo Jung Lim , Yong Sup Suh , Kwon Soo Chun , Soon Hyuk Ahn , Jong Doo Lee , Sung Soon Ho,
Affiliation
Abstract

Purpose : The aim of this sutdy was to evaluate the feasibility of 3-[131I]Iodo-O-methyl-L-a-methyltyrosine ([131I]OMINT) as an agent for tumor image. Materlals and Methods: After synthesis of 4-O-methyl-L-a-methyltyrosine (OMAMT), OMAMT was labeled with 131I using Iodogen method. In viro cellular uptake study was performed using 9 L gliosarcoma cells at various time points upto 4 hr. The biodistribution (five rats implanted with the 9 L gliosarcoma cells per group) was evaluated at 30 min, 2 hr, 24 hr after iv injection of 3.7 MBq [131I]OMIMT or L-3-[131I]iodo-a-methyltyrosine ([131I]IMT). Gamma camera images were obtained at 30min, 2 hr, and 24 hr. Results : [131I]OMINT uptake was 3.3 times and 2.5 times higher than [131I]IMT uptake at 30 min and 60 min, respectively and same after 2 hr in in vitro sutdy using 9L gliosarcoma cells. Maximum accumulation in tumor occurred at 30 min for both [131IOMINT and [131I]IMT in tumor bearing rats. The tumor uptake of [131I]OMINT was significantly higher than that of [131I]IMT in tumor bearing rats. The tumor uptake of [131I]OMIMT was significantly higher than that of [131I]IMT at early time point studied (3.74 +- 0.48 vs 0.38 +- 0.17% ID/g at 30 min and 2.40 +- 0.17 vs 0.24 +- 0.03% ID/g at 2 hr, respectively, p<0.01). However, the tumor uptake of both radiolabels were not significantly different at 24 hr (0.04 +- 0.01 vs 0.05 +- 0.01% ID/g). Tumor was visualized as early as at 30 min in gamma camera images. Conclusion : These data suggested that [131I]OMIMT might be a useful tumor imaging agent and has more advantage for the tumor imaging compared to [131I]IMT. (korean J NuclMed 1998;32;290-7)

Keyword 3-iodo-O-methyl-L-a-methyltyrosine, Tumor, Biodistribution
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