원저 : MELAS 증후군과 미토콘드리아 근육병에서의 Tc-99m ECD 뇌 단일 광전자방출 전산화단층촬영 소견 - 자기공명영상과의 비교 ( Tc-99m ECD Brain SPECT in MELAS Syndrome and Mitochondrial Myopathy - Comparison with MR findings ) () |
Author |
박상준(Sang Joon Park),유영훈(Young Hoon Ryu),전태주(Tae Joo Jeon),김재근(Jai Keun Kim),남지은(Ji Eun Nam),윤평호(Pyeong Ho Yoon),윤춘식(Choon Sik Yoon),이종두(Jong Doo Lee), |
|
Affiliation |
|
Abstract |
Purpose: We evaluated brain perfusion SPECT findings of
MELAS syndrome and mitochondrial myopathy in
correlation with MR imaging in search of specific
imaging features. Materials and Methods: Subjects were
five patients (four females and one male; age range, 1
to 25 year) who presented with repeated stroke-like
episodes, seizures or developmental delay or
asymptomatic but had elevated lactic acid in CSF and
serum. Conventional non-contrast MR imaging and Tc-99m-
ethyl cysteinate dimer (ECD) brain perfusion SPECT were
performed and imaging features were analyzed. Results:
MRI demonstrated increased T2 signal intensities in the
affected areas of gray and white matters mainly in the
parietal (4/5) and occipital lobes (4/5) and in the
basal ganglia (1/5), which were not restricted to a
specific vascular territory. SPECT demonstrated
decreased perfusion in the corresponding regions of MRI
lesions. In addition, there were perfusion defects in
parietal (1 patient), temporal (2), and frontal (1)
lobes and basal ganglia (1) and thalami (2). In a
patient with mitochondrial myopathy who had normal MRI,
decreased perfusion was noted in left parietal area and
bilateral thalami. Conclusion: Tc-99m ECD SPECT imaging
in patients with MELAS syndrome and mitochondrial
myopathy showed hypoperfusion of parieto-occipital
cortex, basal ganglia, thalamus and temporal cortex,
which were not restricted to a specific vascular
territory. There were no specific imaging features on
SPECT. The significance of abnormal perfusion on SPECT
without corresponding MR abnormalities needs to be
evaluated further in larger number of patients. |
Keyword |
Mitochondrial encephalomyopathy, MELAS, Tc-ppm, Brain, Emission tomography, Magnetic resonance imaging |
Full text Article |
28502387.pdf
|
|
|