종양 환자에서 초고에너지 (511 keV) 조준기를 이용한 전신 F-18-FDG 평면 영상 ; Coinxidence 감마카메라 단층 촬영 영상과의 비교 ( F-18-FDG Whole Body Scan using Gamma Camera equipped with Ultra High Energy Collimator in Cancer Patients: Comparison with FDG Co () |
Author |
배문선(Moonsun Pai),박찬희(Chan H Park),조철우(Chul-Woo Joh),윤석남(Se\'ok Nam Yoon),양승대(Seung Dae Yang),임상무(Sang Moo Lim), |
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Affiliation |
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Abstract |
Purpose: The aim of this study is to demonstrate the
feasibility of 2-[fluorine-18] fluoro-2-deoxy-D-glucose
(F-18-FDG) whole body scan (FDG W/B Scan) using dual-
head gamma camera equipped with ultra high energy
collimator in patients with various cancers, and
compare the results with those of coincidence imaging.
Materials and Methods: Phantom studies of planar
imaging with ultra high energy and coincidence
tomography (FDG CoDe PET) were performed. Fourteen
patients with known or suspected maligancy were
examined. F-18-FDG whole body scan was performed using
dual-head gamma camera with high energy (511 keV)
collimators and regional FDG CoDe PET immediately
followed it. Radiological, clinical follow up and
histologic results were correlated with F-18-FDG
finding. Results: Planar phantom study showed 13.1 mm
spatial resolution at 10 cm with a sensitivity of 2638
cpm/MBq/ml. In coincidence PET, spatial resolution was
7.49 mm and sensitivity was 5351 cpm/MBq/ml. Eight out
of 14 patients showed hypermetabolic sites in primary
or metastatic tumors in FDG CoDe PET. The lesions
showing no hypermetabolic uptake of FDG in both methods
were all less than 1 cm except one lesion of 2 cm sized
metastatic lymph node. The metastatic lymph nodes of
positive FDG uptake were more than 1.5 cm in size or
conglomerated lesions of lymph nodes less than 1 cm in
size. FDG W/B scan showed similar results but had
additional false positive and false negative cases. FDG
W/B scan not visualize liver metastasis in one case
that showed multiple metastatic sites in FDG CoDe PET.
Conclusions: FDG W/B scan with specially designed
collimators depicted some cancers and their metastatic
sites, although it had a limitation in image quality
compared to that of FDG CoDe PET. This study suggests
that F-18-FDG positron imaging using dual-head gamma
camera is feasible in oncology and helpful if it should
be more available by regional distribution of FDG. |
Keyword |
Carcinoma, F-18 FDG, Coincidence imaging, Coincidence detection camera, Whole body scan, Positron emission tomography, Ultra high energy collimator |
Full text Article |
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