유방암 진단에 있어서 탈륨스캔과 Tc-99m MIBI 스캔의 비교 ( Comparison of Thallium-201 Scan and Tc-99m Sestamibi Scan in the Differential Diagnosis of Breast Mass ) () |
Author |
조인호(Ihn Ho Cho),원규장(Kyu Jang Won),이형우(Hyung Woo Lee),이수정(Soo Jung Lee), |
|
Affiliation |
|
Abstract |
Purpose: We performed this study to compare T1-201 and
Tc-99m MIBI scans for the differentiation of malignant
from benign breast mass. Materials and Methods: Thirty-
eight female patients underwent T1-201 breast scan and
thirty-two of them also underwent Tc-99m MIBI scan of
the breast. After intravenous injection of 74-111 MBq
of T1-201, early (10 minutes) and delayed (3 hours)
images were obtained. Then, 555-740 MBq of Tc-99m MIBI
was injected and images after 30 minutes were obtained.
We compared T1-201 and Tc-99m MIBI scans with
pathologic results. Results: Twenty-three patients were
confirmed to have infiltrating duct carcinoma and
fifteen patients to have benign breast mass by
excisonal biopsy. The sensitivity of early and delayed
T1-201 scan and Tc-99m MIBI scan in the detection of
malignant breast lesion were 100% (23/23), 82% (18/22),
and 90% (18/20), respectively. The specificity of early
T1-201 scan was significantly higher than that of
delayed T1-201 scan (p<0.05). The specificity of early
and delayed T1-201 scan and Tc-99m MIBI scan were 73%
(11/15), 73% (11/15) and 83% (10/12), respectively
(p:not significant). Three patients out of nine with
fibroadenoma and one patient with atypical duct
hyperplasia were false positive in both early and
delayed T1-201 scans. The size of fibroadenoma with
false positvie in early and delayed T1-201 scan (4
cases) was larger than that of 11 fibradenoma with true
negative scan (p<0.01). Metastatic axillary lymph node
involvement was present in fifteen patients. The
sensitive to detect metastatic nodes was 38% (5/13) for
early T1-201 images, 15% (2/13) for delayed T1-201
images, 58% (7/12) for Tc-99m MIBI planar images and
67% (4/6) for Tc-99m MIBI SPECT. The sensitive of Tc-
99m MIBI planar or SPECT was significantly higher than
that of delayed T1-201 images (p<0.05). Conclusion:
Early T1-201 and Tc-99m MIBI scan are useful
noninvasive methods to differentiate malignant form
benign mass of breast. Tc-99m MIBI scan was sensitive
in detecting axillary lymph node metastasis in patients
with brease cancer. |
Keyword |
T1-201, Tc-99m MIBT, Breast neoplasms, Infiltrating duct carcinoma, Radionuclide imaging |
Full text Article |
28501968.pdf
|
|
|