한국 정상인에서 연령에 따른 뇌혈류분포와 혈류예비능의 변화 : Tc-99m HMPAO SPECT 에 의한 연구 ( Change of Cerebral Blood Flow Distribution and Vascular Reserve according to Age in Koreans Measured by Tc-99m HMPAO Brain SPECT ) () |
Author |
송호천(Ho Cheon Song),범희승(Hee-Seung Bom),손혜경(Hye-Kyung Sohn),정환정(Hwan-Jeong Jeong),민정준(Jung-Jun Min),김지열(Ji-Yeul Kim),이재태(Jaetae Lee),문대혁(Dae Hyuk Moon),이희경(Hee Kyung Lee), |
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Affiliation |
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Abstract |
Purpose: The aim of this study was to evaluate the
normal values of regional cerebral blood flow (rCBF)
and cerebrovascular reserve (CVR) in normal children to
aged volunteers using Tc-99m HMPAO. Materials and
Methods: Thirty four right-handed normal volunteers (20
males, 14 females, mean age 40.3¡¾24.9 years, range 4
to 82 years) were underwent rest/acetazolamide (ACZ)
brain SPECT using Tc-99m HMPAO and the sequential
injection and subtraction method. rCBF was estimated on
the basis of a semiquantitative approach by means of
right/left ratio, region/cerebellum and region to whole
brain ratios in frontal, parietal, temporal, and
occipital lobes, basal ganglia, thalami, and
cerebellum. CVR was measured by means of % perfusion
increase calculated as % mean count change compared to
rest rCBF in each regions. Results: Mean values of
right to left ratios range from 1.004 to 1.018. rCBF
was highest in cerebellum and lowest in basal ganglia
and thalami. Frontal and temporal rCBF decreased while
occipital and thalamic rCBF increased according to age.
No sexual difference of rCBF was noted. Mean CVR was
29.9¡¾12.9%. Mean CVR significantly increased to late
teens, and declined thereafter. After 6th decade, CVR
in both frontal lobes, left parietal lobe and right
basal ganglia decreased significantly with advancing
age. There was no sexual difference of CVR. Conclusion:
Quantitative assessment of CVR was possible by ACZ Tc-
99m HMPAO brain SPECT. It revealed that rCBF and CVR
changed according to age in normal Korean volunteers.
There was no sexual difference. |
Keyword |
Cerebral blood flow, Cerebrovascular reserve, Acetazolamide, Tc-99m HMPAO, Brain, Singlphoton emission computed tomography, Normal control study |
Full text Article |
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