N-13 암모니아 PET 동적영상과 인자분석을 이용한 심근 혈류량 정량화 ( Quantification of Myocardial Blood flow using Dynamic N-13 Ammonia PET and factor Analysis ) () |
Author |
최용(Yong Choi),김준영(Joon Young Kim),임기천(Ki Chun Im),김종호(Jong Ho Kim),우상근(Sang Keun Woo),이경한(Kyung Han Lee),김상은(Sang Eun Kim),최연성(Yearn Seong Choe),김병태(Byung-Tae Kim), |
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Affiliation |
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Abstract |
Purpose: We evaluated the feasibility of extracting
pure left ventricular blood pool and myocardial time-
activity curves (TACs) and of generating factor images
from human dynamic N-13 ammonia PET using factor
analysis. The myocardial blood flow (MBF) estimates
obtained with factor analysis were compared with those
obtained with the user drawn region-of-interest (ROI)
method. Materials and Methods: Stress and rest N-13
ammonia cardiac PET imaging was acquired for 23 min in
5 patients with coronary artery disease using GE
Advance tomograph. Factor analysis generated
physiological TACs and factor images using the
normalized TACs from each dixel. Four steps were
involved in this algorithm: (a) data preprocessing; (b)
principal component analysis; (c) oblique rotation with
positivity constraints; (d) factor image computation.
Area under curves and MBF estimated using the two
compartment N-13 ammonia model were used to validate
the accuracy of the factor analysis generated
physiological TACs. The MBF estimated by factor
analysis was compared to the values estimated by using
the ROI method. Results: MBF values obtained by factor
analysis were linearly correlated with MBF obtained by
the ROI method (slope=0.84, r=0.91). Left ventricular
blood pool TACs obtained by the two methods agreed well
(Area under curve ratio: 1.02 (0∼1 min), 0.98 (0∼2
min), 0.86 (1∼2 min)). Conclusion: The results of this
study demonstrates that MBF can be measured accurately
and noninvasively with dynamic N-13 ammonia PET imaging
and factor analysis. This method is simple and
accurate, and can measure MBF without blood sampling,
ROI definition or spillover correction. KW: N-13
ammonia, PET, Myocardial blood flow, Factor analysis |
Keyword |
N-13 ammonia, PET, Myocardial blood flow, Factor analysis |
Full text Article |
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