안구 내 종양의 진단에 있어서 F-18-FDG PET의 유용성과 검사 방법의 영향( The Usefulness of F-18-FDG PET and The Effect of Scan Protocol in Diagnosis of Intraocular Tumors ) () |
Author |
이재성(Jae Sung Lee),양원일(Weon Il Yang),김병일(Byeung Il Kim),최창운(Chang Woon Choi),임상무(Sang Moo Lim),이태원(Tae Won Lee),신민경(Min Kyeung Sim),홍성운(Seong Woon Hong), |
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Affiliation |
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Abstract |
Purpose: It is important to differentiate malignant
from benign lesions of intraocular masses in choosing
therapeutic plan. Biopsy of intraocular tumor is not
recommended due to the risk of visual damage. We
evaluated the usefulness of F-18-FDG PET imaging in
diagnosing intraocular neoplasms. Materials and
Methods: F-l8-FDG PET scan was performed in 13 patients
(15 lesions) suspected to have malignant intraocular
tumors. There were 3 benign lesions (retinal
detachment, choroidal effusion and hemorrhage) and 10
patients with 12 malignant lesions (3 melanomas, 7
retinoblastomas and 2 metastatic cancers). Regional eye
images (256*256 and 128*128 matrices) were obtained
with or without attenuation correction. Whole body scan
was also performed in eight patients (3 benign and 6
malignant lesions). Results: All malignant lesions were
visualized while all benign lesions were not
visualized. The mean peak standardized uptake value
(SUV) of malignant lesions was 2.64+-0.57 g/ml. There
was no correlations between peak SUV and tumor volume.
Two large malignant lesions (>1000 mm3 ) showed hot
uptake on whole body scan. But two medium-sized lesions
(100-l000 mm3) looked faint and two small (<100 mm3)
lesions were not visualized. The images reconstructed
with 256*256 matrix showed lesions more clearly than
those with 128X128 matrix. Conclusion: F-18-FDG PET
scan is highly sensitivity in detecting malignant
intraocular tumor. For the evaluation of small-sized
intraocular lesions, whole body scan is not appropriate
because of low sensitivity. A regional scan with
sufficient acquisition time is recommended for that
purpose. Image reconstruction in matrix size of 256*256
produced clearer images than the ones in 128X128, but
it does not affect the diagnostic sensitivity. (Korean
J Nucl Med 1999;33:439-451)
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Keyword |
Orbital neoplasms, Fluorine-18 FDG, Positron emission tomography |
Full text Article |
28502427.pdf
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