분화성 갑상선암의 원격 전이에서 방사성옥소 치료 성적 ( Results of Radioiodine Treatment for Distant Metastases of Differentiated Thyroid Carcinoma )
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Author |
김유경(Yu Kyeong Kim),정준기(June Key Chung),김석기(Seok Ki Kim),여정석(Jung Seok Yeo),박도준(Do Joon Park),정재민(Jae Min Jeong),이동수(Dong Soo Lee),조보연(Bo Youn Cho),이명철(Myung Chul Lee), |
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Affiliation |
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Abstract |
Purpose: To evaluate the effectiveness of radioiodine treatment for metastatic thyroid carcinoma, we reviewed results of radioactive iodine treatment in patients with functional lung or bone metastases. Materials and Methods: Of 760 patients who were treated for differentiated thyroid cancer between 1984 and 1998, we detected pulmonary metastases and bone metastases in 76 patients (10.0%) and 20 patients (2.6%), respectively. Among them, we could evaluate the effectiveness of I-131 therapy in 53 patients with lung metastases and 15 patients with bone metastases. Results: Of 53 patients who received I-131 therapy with a mean cumulative dose of 26.2 GBq (1.1-84.4 GBq) for pulmonary metastases, metastatic lung lesions completely resolved in 19 patients (35.8%) and improved in 22 patients (41.5%). In 13 of 19 patients with complete remission of pulmonary metastases, the total accumulated dose of I-131 was less than 18.5 GBq. We found 43 sites of metastatic bone lesions in 15 patients with bone metastases. Of 29 lesions which received I-131 therapy, metastatic lesions improved in 14 sites (48.3%), but did not change or progress in 15 sites (51.7%) despite the I-131 therapy. Three lesions were completely cured with a combination treatment of surgery(¡¾ external radiotherapy) and I-131 therapy, and the other 11 lesions improved. Conclusion: Radioactive iodine treatment gives favorable results for pulmonary metastases. However, for bone metastases, there might be a need to use combination therapy including I-131 and surgery or external irradiation. (Korean J Nucl Med 2000;34:107-118)
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Keyword |
differentiated thyroid cancer, lung metastasis, bone metastasis, I-131 treatment |
Full text Article |
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