원저 : 전두엽 간질에서 F - 18 - FDG PET 의 간질병소 국소화 성능 ; 육안 판독과 SPM 에 의한 분석 ( Orginal Articles : Brain F - 18 FDG PET for localization of epileptogenic zones in frontal lobe epilepsy ; visual assessment and statistical parametric mappin () |
Author |
김유경(Yu Kyeong Kim),이동수(Dong Soo Lee),이상건(Sang Kun Lee),정천기(Chun Kee Chung),여정석(Jeong Seok Yeo),정준기(June Key Chung),이명철(Myung Chul Lee), |
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Abstract |
Purpose: We evaluated the sensitivity of the F-18 FDG PET by visual assessment and statistical parametric mapping (SPM) analysis for the localization of the epileptogenic zones in frontal lobe epilepsy. Materials and Methods: Twenty-four patients with frontal lobe epilepsy were examined. All patients exhibited improvements after surgical resection (Engel class I or II). Upon pathological examination, 18 patients revealed cortical dysplasia, 4 patients revealed tumor, and 2 patients revealed cortical scar. The hypometabolic lesions were found in F-18 FDG PET by visual assessment and SPM analysis. On SPM analysis, cutoff threshold was changed. Results: MRI showed structural lesions in 12 patients and normal results in the remaining 12. F-18 FDG PET correctly localized epileptogenic zones in 13 patients (54%) by visual assessment. Sensitivity of F-18 FDG PET in MR-negative patients (50%) was similar to that in MR-positive patients (67%). On SPM analysis, sensitivity decreased according to the decrease of p value. Using uncorrected p value of 0.05 as threshold, sensitivity of SPM analysis was 63%, which was not statistically different from that of visual assessment. Conclusion: F-18 FDG PET was sensitive in finding epileptogenic zones by revealing hypometabolic areas even in MR-negative patients with frontal lobe epilepsy as well as in MR-positive patients. SPM analysis showed comparable sensitivity to visual assessment and could be used as an aid in the diagnosis of epileptogenic zones in frontal lobe epilepsy. (Korean J Nucl Med 200135:131-141) |
Keyword |
Frontal lobe epilepsy , F - 18 FDG PET , Statistical parametric mapping ( SPM ) |
Full text Article |
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