인삼 사포닌이 흰쥐 측핵과 선조체에서 니코틴에 의한 도파민 유리에 미치는 효과
(Effect of Ginseng Saponins on Nicotine-Induced Dopamine Release in the Rat Nucleus Accumbens and Striatum) |
| Author |
김상은1, 심인섭2, 정준기3, 이명철, |
| Sang Eun Kim, M.D., Ph.D.1, Insop Shim, Ph.D.2, June-Key Chung, M.D., Ph.D.3 |
| Affiliation |
성균관대학교 의과대학 삼성서울병원 핵의학과1, 경희대학교 동서의학대학원2, 서울대학교 의과대학 핵의학교실3
Department of Nuclear Medicine1, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea; Graduate School of East-West Medical Science2, Kyung Hee University, Seoul, Korea; and Department of Nuclear Medicine3, Seoul National Univ |
| Abstract |
Purpose and Methods: We investigated the effect of ginseng total saponin (GTS) on nicotine-induced dopamine (DA) release in the striatum and nucleus accumbens of freely moving rats using in vivo microdialysis technique. Results: Systemic pretreatment with GTS decreased striatal DA release induced by local infusion of nicotine into the striatum. However, GTS had no effect on the resting levels of extracellular DA in the striatum. GTS also blocked nicotine-induced DA release in the nucleus accumbens. Conclusion: The results of the present study suggest that GTS acts on the DA terminals to prevent DA release induced by nicotine. This may reflect the blocking effect of GTS on behavioral hyperactivity induced by psychostimulants. (Korean J Nucl Med 2002;36;277-87)
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| Keyword |
Ginseng saponins, Nicotine, Dopamine release, Striatum, Nucleus accumbens |
| Full text Article |
36050277.pdf 
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