조기 알츠하이머 치매의 뇌포도당 대사 감소 평가에서 오류발견률 조절법의 적용 (Application of False Discovery Rate Control in the Assessment of Decrease of FDG Uptake in Early Alzheimer Dementia) |
Author |
이동수,강혜진,장명진,조상수,강원준,이재성,강은주,이강욱,우종인,이명철, |
Dong Soo Lee, M.D.,Hyejin Kang, M.S.,Myung Jin Jang, M.S.,Sang Soo Cho, M.S.,Won Jun Kang M.D., Jae Sung Lee, Ph.D.,Eunjoo Kang, Ph.D.,Kang Uk Lee, M.D.,Jong In Woo, M.D.,Myung Chul Lee, M.D. |
Affiliation |
서울대학교 의과대학 핵의학교실,신경정신과학교실,성균관대학교 인지과학전공 Departments of Nuclear Medicine,and Neuropsychiatry,Seoul National University, and InterdisciplinaryProgram in Cognitive Science,Sungkyunkwan University, Seoul, Korea |
Abstract |
Purpose: Determining an appropriate thresholding is crucial for PDG PET analysis since strong control of
Type I error could fail to find pathological differences between early Alzheimer’ disease (AD) patients and
healthy normal controls. We compared the SPM results on FDG PET imaging of early AD using uncorrected
p-value, random-field based corrected p-value and false discovery rate (FDR) control. Materials and
Methods: Twenty-eight patients (66±7 years old) with early AD and 18 age-matched normal controls (68±6
years old) underwent FDG brain PET. To identify brain regions with hypo-metabolism in group or individual
patient compared to normal controls, group images or each patient's image was compared with normal
controls usingthe same fixed p-value of 0.001 on uncorrected thresholding, random-field based corrected
thresholding and FDR control. Results: The number of hypo-metabolic voxels was smallest in corrected
p-value method, largest in uncorrected p-value method and intermediate in FDG thresholding in group
analysis. Three types of result pattern were found. The first was that corrected p-value did not yield any
voxel positive but FDR gave a few significantly hypometabolic voxels (8/28, 29%). The second was that both
corrected p-value and FDR did not yield any positive region but numerous positive voxels were found with
the threshold of uncorrected p-values (6/28, 21%). The last was that FDR was detected as many positive
voxels as uncorrected p-value method (14/28, 50%). Conclusions FDR control could identify hypo-metabolic
areas in group or individual patients with early AD. We recommend FDR control instead of uncorrected or
random-field corrected thresholding method to find the areas showing hypometabolism especially in small
group or individual analysis of FDG PET. |
Keyword |
false discovery rate, Alzheimer dementia, FDG uptake, statistical parametric mapping |
Full text Article |
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