핵의학적 리포터 유전자 영상 (Radionuclide Reporter Gene Imaging) |
Author |
민정준, |
Jung-Joon Min, M.D., PhD. |
Affiliation |
전남대학교 의과대학 핵의학교실 Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju, Korea |
Abstract |
Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of
molecular imaging biological research. These tools have been validated recently in variety of research models, and
have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation
of gene expression. This article reviews the principles, characteristics, categories and the use of radionuclide
reporter gene imaging technologies as they have been used in imaging cell trafficking, imaging gene therapy,
imaging endogenous gene expression and imaging molecular interactions. The studies published to date
demonstrate that reporter gene imaging technologies will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases. (Korean J Nucl Med 38(2):143-151, 2004) |
Keyword |
Reporter gene, Imaging |
Full text Article |
3802143.pdf
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