분자핵의학 기법을 이용한 다약제내성 진단 (Detection of Multidrug Resistance Using Molecular Nuclear Technique) |
Author |
이재태,안병철, |
Jaetae Lee, M.D., Byeong-Cheol Ahn, M.D. |
Affiliation |
경북대학교 의과대학 핵의학교실 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Korea |
Abstract |
Although the outcome of cancer patients after cytotoxic chemotherapy is related diverse mechanisms, multidrug
resistance (MDR) for chemotherapeutic drugs due to cellular P-glycoprotein (Pgp) or multidrug-resistance associated
protein (MRP) is most important factor in the chemotherapy failure to cancer. A large number of pharmacologic
compounds, including verapamil, quinidine, tamoxifen, cyclosporin A and quinolone derivatives have been reported to
overcome MDR. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are
available for the detection of Pgp and MRP-mediated transporter. 99mTc-MIBI and other 99mTc-radiopharmaceuticals
are substrates for Pgp and MRP, and have been used in clinical studies for tumor imaging, and to visualize
blockade of Pgp-mediated transport after modulation of Pgp pump. Colchicine, verapamil and daunorubicin labeled
with 11C have been evaluated for the quantification of Pgp-mediated transport with PET in vivo and reported to
be feasible substrates with which to image Pgp function in tumors. Leukotrienes are specific substrates for MRP
and N-[11C]acetyl-leukotriene E4 provides an opportunity to study MRP function non-invasively in vivo. SPECT and
PET pharmaceuticals have successfully used to evaluate pharmacologic effects of MDR modulators. Imaging of
MDR and reversal of MDR with bioluminescence in a living animal is also evaluated for future clinical trial. We
have described recent advances in molecular imaging of MDR and reviewed recent publications regarding
feasibility of SPECT and PET imaging to study the functionality of MDR transporters in vivo. (Korean J Nucl Med 38(2):180-189, 2004) |
Keyword |
Multidrug resistance, MDR Modulator, Molecular imaging, SPECT, PET, Bioluminescence |
Full text Article |
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